PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| serpin family E member 3 | ENSG00000253309 | SERPINE3 | chr13:51335773-51364735:+ | Tdark | 0.166667 |
| carbonic anhydrase 7 | ENSG00000168748 | CA7 | chr16:66844379-66854153:+ | Tclin | 38.789 |
| 5-hydroxytryptamine receptor 5A | ENSG00000157219 | HTR5A | chr7:155070324-155085749:+ | Tchem | 58.375 |
| defensin beta 116 | ENSG00000215545 | DEFB116 | chr20:31303212-31308585:- | Tdark | 0 |
| olfactory receptor family 2 subfamily T member 27 | ENSG00000187701 | OR2T27 | chr1:248649931-248650884:- | Tdark | 0 |
| pyrimidinergic receptor P2Y4 | ENSG00000186912 | P2RY4 | chrX:70258170-70259764:- | Tchem | 89.0243 |
| olfactory receptor family 51 subfamily F member 2 | ENSG00000176925 | OR51F2 | chr11:4821386-4822414:+ | Tdark | 0 |
| transmembrane serine protease 12 | ENSG00000186452 | TMPRSS12 | chr12:50842920-50887884:+ | Tdark | 0.166667 |
| olfactory receptor family 4 subfamily N member 5 | ENSG00000184394 | OR4N5 | chr14:20143736-20144662:+ | Tdark | 0 |
| olfactory receptor family 56 subfamily A member 5 | ENSG00000188691 | OR56A5 | chr11:5967177-5968494:- | Tdark | 0 |
| serine protease 37 | ENSG00000165076 | PRSS37 | chr7:141836286-141841487:- | Tdark | 0.090909 |
| olfactory receptor family 2 subfamily M member 5 | ENSG00000162727 | OR2M5 | chr1:248145148-248146086:+ | Tdark | 0 |
| olfactory receptor family 2 subfamily J member 3 | ENSG00000204701 | OR2J3 | chr6:29111891-29112826:+ | Tdark | 47.0262 |
| baculoviral IAP repeat containing 8 | ENSG00000163098 | BIRC8 | chr19:53289601-53291626:- | Tchem | 5.8816 |
| ovochymase 2 | ENSG00000183378 | OVCH2 | chr11:7689438-7706421:- | Tdark | 1 |
| olfactory receptor family 7 subfamily E member 24 | ENSG00000237521 | OR7E24 | chr19:9250930-9252479:+ | Tdark | 14.8333 |
| olfactory receptor family 2 subfamily G member 6 | ENSG00000188558 | OR2G6 | chr1:248521647-248522597:+ | Tdark | 0 |
| olfactory receptor family 1 subfamily M member 1 | ENSG00000170929 | OR1M1 | chr19:9093179-9094213:+ | Tdark | 32.75 |
| olfactory receptor family 2 subfamily G member 3 | ENSG00000177476 | OR2G3 | chr1:247605586-247606515:+ | Tdark | 28.4167 |
| olfactory receptor family 10 subfamily AG member 1 | ENSG00000174970 | OR10AG1 | chr11:55967558-55968463:- | Tdark | 0 |
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