PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| opiorphin prepropeptide | ENSG00000171199 | PROL1 | chr4:70397882-70410194:+ | Tdark | 33.1429 |
| olfactory receptor family 4 subfamily C member 6 | ENSG00000181903 | OR4C6 | chr11:55665167-55666096:+ | Tdark | 0.326923 |
| olfactory receptor family 2 subfamily T member 10 | ENSG00000184022 | OR2T10 | chr1:248592830-248593768:- | Tdark | 0 |
| CUB domain containing protein 2 | ENSG00000157211 | CDCP2 | chr1:54133074-54153770:- | Tdark | 2 |
| MAS related GPR family member X1 | ENSG00000170255 | MRGPRX1 | chr11:18933813-18939507:- | Tchem | 14.8429 |
| secretoglobin family 1D member 4 | ENSG00000197745 | SCGB1D4 | chr11:62296277-62299064:- | Tdark | 5.88333 |
| histatin 3 | ENSG00000205649 | HTN3 | chr4:70028413-70036538:+ | Tbio | 21.5833 |
| nyctalopin | ENSG00000188937 | NYX | chrX:41447434-41475710:+ | Tbio | 79.2262 |
| olfactory receptor family 2 subfamily M member 4 | ENSG00000171180 | OR2M4 | chr1:248238929-248239864:+ | Tdark | 19.875 |
| transglutaminase 7 | ENSG00000159495 | TGM7 | chr15:43276280-43302255:- | Tdark | 3.81111 |
| GLIPR1 like 1 | ENSG00000173401 | GLIPR1L1 | chr12:75334639-75370560:+ | Tdark | 1.0373 |
| ADAM metallopeptidase domain 21 | ENSG00000139985 | ADAM21 | chr14:70452157-70459899:+ | Tdark | 3.56667 |
| SH3 domain binding kinase family member 3 | ENSG00000231274 | SBK3 | chr19:55540656-55545543:- | Tchem | 0 |
| olfactory receptor family 2 subfamily Z member 1 | ENSG00000181733 | OR2Z1 | chr19:8730954-8732009:+ | Tdark | 49.4167 |
| submaxillary gland androgen regulated protein 3A | ENSG00000109208 | SMR3A | chr4:70360761-70367158:+ | Tdark | 4 |
| phospholipid scramblase 2 | ENSG00000163746 | PLSCR2 | chr3:146391421-146495991:- | Tdark | 1.79461 |
| lysine demethylase 4E | ENSG00000235268 | KDM4E | chr11:95025258-95027596:+ | Tchem | 5.65833 |
| solute carrier family 6 member 18 | ENSG00000164363 | SLC6A18 | chr5:1225355-1246189:+ | Tbio | 7.74359 |
| olfactory receptor family 14 subfamily I member 1 | ENSG00000189181 | OR14I1 | chr1:248681369-248682304:- | Tdark | 0 |
| adhesion G protein-coupled receptor D2 | ENSG00000180264 | ADGRD2 | chr9:124451600-124478589:+ | Tdark | 0.250549 |
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