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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
protein arginine methyltransferase 8	ENSG00000111218	PRMT8	chr12:3381349-3593973:+	Tchem	11.0733
olfactory receptor family 2 subfamily AK member 2	ENSG00000187080	OR2AK2	chr1:247965233-247966339:+	Tdark	1.14286
collagen type VI alpha 5 chain	ENSG00000172752	COL6A5	chr3:130345516-130484844:+	Tbio	11.7595
cyclin dependent kinase 15	ENSG00000138395	CDK15	chr2:201790461-201895550:+	Tchem	0.694444
olfactory receptor family 13 subfamily J member 1	ENSG00000168828	OR13J1	chr9:35869263-35870601:-	Tdark	11.4167
dual specificity phosphatase 21	ENSG00000189037	DUSP21	chrX:44844004-44844888:+	Tdark	1
olfactory receptor family 1 subfamily J member 2	ENSG00000197233	OR1J2	chr9:122510802-122511743:+	Tdark	14.7278
cystatin 8	ENSG00000125815	CST8	chr20:23491101-23496018:+	Tbio	52.8679
serine peptidase inhibitor, Kunitz type 3	ENSG00000101446	SPINT3	chr20:45512461-45515624:-	Tdark	0
olfactory receptor family 7 subfamily G member 2	ENSG00000170923	OR7G2	chr19:9102269-9103306:-	Tdark	0.833333
ADAM metallopeptidase domain 32	ENSG00000197140	ADAM32	chr8:39106990-39284911:+	Tdark	1
phospholipase A2 group IIE	ENSG00000188784	PLA2G2E	chr1:19920009-19923617:-	Tchem	1.98333
serine protease 45, pseudogene	ENSG00000188086	PRSS45	chr3:46742092-46812558:-	Tdark	0
olfactory receptor family 4 subfamily F member 4	ENSG00000177693	OR4F4	chr15:101922042-101923095:-	Tdark	0
olfactory receptor family 2 subfamily W member 1	ENSG00000204704	OR2W1	chr6:29044213-29045240:-	Tdark	0.2
olfactory receptor family 5 subfamily K member 2	ENSG00000231861	OR5K2	chr3:98497604-98498663:+	Tdark	49.5167
olfactory receptor family 7 subfamily D member 2	ENSG00000188000	OR7D2	chr19:9185594-9188817:+	Tdark	2.5
vomeronasal 1 receptor 2	ENSG00000196131	VN1R2	chr19:53258292-53261837:+	Tdark	2.64286
olfactory receptor family 11 subfamily L member 1	ENSG00000197591	OR11L1	chr1:247840928-247841896:-	Tdark	0
olfactory receptor family 52 subfamily L member 1	ENSG00000183313	OR52L1	chr11:5985892-5986985:-	Tdark	0.1

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