PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
neuropeptide VF precursorENSG00000105954NPVFchr7:25224570-25228486:-Tdark117.067
olfactory receptor family 5 subfamily P member 3ENSG00000182334OR5P3chr11:7825037-7825972:-Tdark0.45
olfactory receptor family 6 subfamily K member 6ENSG00000180433OR6K6chr1:158754720-158755891:+Tdark14.3333
potassium calcium-activated channel subfamily U member 1ENSG00000215262KCNU1chr8:36784324-36936128:+Tbio14.0833
taste 2 receptor member 1ENSG00000169777TAS2R1chr5:9628997-9712378:-Tbio9.59444
olfactory receptor family 11 subfamily H member 4ENSG00000176198OR11H4chr14:20242739-20243820:+Tdark0
solute carrier family 36 member 2ENSG00000186335SLC36A2chr5:151314978-151347590:-Tbio20.5417
phosphoribosyl pyrophosphate synthetase 1 like 1ENSG00000229937PRPS1L1chr7:18026774-18027863:-Tdark2.94286
olfactory receptor family 51 subfamily B member 4ENSG00000183251OR51B4chr11:5301014-5301996:-Tdark0.552632
H4 clustered histone 2ENSG00000278705HIST1H4Bchr6:26026815-26027252:-0
opticinENSG00000188770OPTCchr1:203494143-203508864:+Tbio32.7
transmembrane serine protease 11BENSG00000185873TMPRSS11Bchr4:68226653-68245720:-Tdark1.5
dual specificity phosphatase 29ENSG00000188716DUPD1chr10:75037836-75058514:-Tbio1.25
olfactory receptor family 1 subfamily E member 1ENSG00000180016OR1E1chr17:3397104-3398410:-Tdark1.1
olfactory receptor family 2 subfamily T member 8ENSG00000177462OR2T8chr1:247921018-247921956:+Tdark0
olfactory receptor family 3 subfamily A member 2ENSG00000221882OR3A2chr17:3277899-3278974:-Tdark10.3333
olfactory receptor family 2 subfamily H member 2ENSG00000204657OR2H2chr6:29587455-29589038:+Tbio5.09286
MAS related GPR family member X4ENSG00000179817MRGPRX4chr11:18172837-18197348:+Tdark0.459524
solute carrier family 17 member 8ENSG00000179520SLC17A8chr12:100357079-100422059:+Tbio33.1536
testis expressed 101ENSG00000131126TEX101chr19:43401496-43418597:+Tbio13.7179

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