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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
protein disulfide isomerase like, testis expressed	ENSG00000169340	PDILT	chr16:20359170-20404737:-	Tdark	3.39444
trace amine associated receptor 6	ENSG00000146383	TAAR6	chr6:132570322-132571359:+	Tbio	79.8603
solute carrier family 35 member G5	ENSG00000177710	SLC35G5	chr8:11330888-11332208:+	Tbio	20.9728
defensin beta 118	ENSG00000131068	DEFB118	chr20:31368618-31373923:+	Tbio	6
olfactory receptor family 4 subfamily F member 29	ENSG00000278566	OR4F29	chr1:450740-451678:-	Tdark	254.586
taste 1 receptor member 2	ENSG00000179002	TAS1R2	chr1:18839599-18859682:-	Tbio	60.7214
olfactory receptor family 10 subfamily H member 1	ENSG00000186723	OR10H1	chr19:15807003-15808126:-	Tdark	0.5
G protein-coupled receptor 152	ENSG00000175514	GPR152	chr11:67451301-67452729:-	Tbio	17.6444
olfactory receptor family 10 subfamily T member 2	ENSG00000186306	OR10T2	chr1:158398522-158399466:-	Tdark	126.726
lipocalin 8	ENSG00000204001	LCN8	chr9:136754386-136758543:-	Tbio	3.575
cystatin 11	ENSG00000125831	CST11	chr20:23450403-23452857:-	Tbio	3.33333
solute carrier organic anion transporter family member 6A1	ENSG00000205359	SLCO6A1	chr5:102371782-102499016:-	Tbio	3.88849
olfactory receptor family 6 subfamily K member 3	ENSG00000203757	OR6K3	chr1:158717168-158718163:-	Tdark	16.65
lysozyme like 4	ENSG00000157093	LYZL4	chr3:42397078-42410600:-	Tbio	6.45
kelch like family member 1	ENSG00000150361	KLHL1	chr13:69700594-70108493:-	Tbio	6.36978
casein kappa	ENSG00000171209	CSN3	chr4:70242588-70251428:+	Tbio	65.6763
interphotoreceptor matrix proteoglycan 1	ENSG00000112706	IMPG1	chr6:75921115-76072678:-	Tbio	17.1167
methyltransferase like 21C	ENSG00000139780	METTL21C	chr13:102685744-102694504:-	Tdark	0.2
synaptotagmin 15	ENSG00000204176	SYT15	chr10:46578217-46594173:+	Tdark	0.5
pepsinogen A5	ENSG00000256713	PGA5	chr11:61241042-61251448:+	Tclin	87.4326

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