PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
olfactory receptor family 6 subfamily F member 1ENSG00000169214OR6F1chr1:247711829-247712755:-Tdark39.4167
angiopoietin 4ENSG00000101280ANGPT4chr20:869899-916317:-Tbio22.4997
olfactory receptor family 6 subfamily B member 2ENSG00000182083OR6B2chr2:240028965-240030456:-Tdark240.8
olfactory receptor family 51 subfamily T member 1ENSG00000176900OR51T1chr11:4881819-4882883:+Tdark0
interphotoreceptor matrix proteoglycan 2ENSG00000081148IMPG2chr3:101222546-101320560:-Tbio12.75
lipase IENSG00000188992LIPIchr21:14108813-14210891:-Tbio10.5588
homeodomain interacting protein kinase 4ENSG00000160396HIPK4chr19:40379271-40390187:-Tchem1.08333
cytochrome P450 family 3 subfamily A member 43ENSG00000021461CYP3A43chr7:99828013-99866102:+Tclin22.9403
cysteine rich secretory protein 1ENSG00000124812CRISP1chr6:49834257-49877096:-Tbio38.2768
FRAS1 related extracellular matrix 3ENSG00000183090FREM3chr4:143577302-143700675:-Tdark2.35
olfactory receptor family 2 subfamily K member 2ENSG00000171133OR2K2chr9:111327483-111328520:-Tdark0.333333
C1q and TNF related 9BENSG00000205863C1QTNF9Bchr13:23891099-23902655:-Tdark1.45833
C1q and TNF related 9ENSG00000240654C1QTNF9chr13:24307166-24322535:+Tbio6.01786
olfactory receptor family 4 subfamily K member 1ENSG00000155249OR4K1chr14:19935608-19936683:+Tdark0
taste 2 receptor member 42ENSG00000186136TAS2R42chr12:11185993-11186937:-Tdark1.83333
BPI fold containing family B member 3ENSG00000186190BPIFB3chr20:33055424-33073628:+Tdark1.53333
solute carrier family 22 member 13ENSG00000172940SLC22A13chr3:38265812-38278315:+Tbio10.3075
ovochymase 1ENSG00000187950OVCH1chr12:29412474-29497686:-Tdark0
carboxylesterase 5AENSG00000159398CES5Achr16:55846154-55956031:-Tbio12.0833
epididymal sperm binding protein 1ENSG00000169393ELSPBP1chr19:47994651-48025153:+Tbio42.3804

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