PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| astacin like metalloendopeptidase | ENSG00000188886 | ASTL | chr2:96123850-96138436:- | Tbio | 5.16667 |
| bombesin receptor subtype 3 | ENSG00000102239 | BRS3 | chrX:136487887-136493780:+ | Tchem | 84.1151 |
| meprin A subunit beta | ENSG00000141434 | MEP1B | chr18:32185069-32220404:+ | Tbio | 37.1083 |
| PR/SET domain 7 | ENSG00000126856 | PRDM7 | chr16:90056566-90092072:- | Tdark | 2.86111 |
| killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 | ENSG00000242019 | KIR3DL3 | chr19:54724479-54736536:+ | Tbio | 18.1334 |
| MAS1 proto-oncogene like, G protein-coupled receptor | ENSG00000204687 | MAS1L | chr6:29486697-29487956:- | Tbio | 38.1679 |
| lipase family member J | ENSG00000204022 | LIPJ | chr10:88586753-88606976:+ | Tbio | 2.1 |
| olfactory receptor family 2 subfamily T member 1 | ENSG00000175143 | OR2T1 | chr1:248405995-248407104:+ | Tdark | 33.1167 |
| amylase alpha 2A | ENSG00000243480 | AMY2A | chr1:103616811-103625780:+ | Tclin | 53.4977 |
| G protein-coupled receptor 119 | ENSG00000147262 | GPR119 | chrX:130384440-130385447:- | Tchem | 75.6782 |
| adhesion G protein-coupled receptor E3 | ENSG00000131355 | ADGRE3 | chr19:14619117-14690027:- | Tbio | 8.73706 |
| G protein-coupled receptor 142 | ENSG00000257008 | GPR142 | chr17:74367407-74372622:+ | Tchem | 3.79127 |
| olfactory receptor family 10 subfamily A member 3 | ENSG00000170683 | OR10A3 | chr11:7938534-7939594:- | Tdark | 1.04762 |
| olfactory receptor family 2 subfamily M member 7 | ENSG00000177186 | OR2M7 | chr1:248323630-248324568:- | Tdark | 12.0714 |
| olfactory receptor family 2 subfamily B member 2 | ENSG00000168131 | OR2B2 | chr6:27911185-27912396:- | Tdark | 0 |
| Wnt family member 8A | ENSG00000061492 | WNT8A | chr5:138083892-138092365:+ | Tbio | 10.6398 |
| G protein-coupled receptor 52 | ENSG00000203737 | GPR52 | chr1:174448111-174449198:+ | Tchem | 1.49405 |
| solute carrier family 25 member 2 | ENSG00000120329 | SLC25A2 | chr5:141302629-141304045:- | Tbio | 3.95833 |
| olfactory receptor family 7 subfamily C member 2 | ENSG00000127529 | OR7C2 | chr19:14941489-14942448:+ | Tdark | 0.5 |
| olfactory receptor family 2 subfamily H member 1 | ENSG00000204688 | OR2H1 | chr6:29457181-29464328:+ | Tdark | 52.5429 |
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