PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| solute carrier family 34 member 3 | ENSG00000198569 | SLC34A3 | chr9:137230757-137236554:+ | Tbio | 33.0778 |
| olfactory receptor family 2 subfamily T member 29 | ENSG00000182783 | OR2T29 | chr1:248558544-248559491:- | Tdark | 0 |
| matrilin 4 | ENSG00000124159 | MATN4 | chr20:45293445-45308529:- | Tbio | 12.2972 |
| olfactory receptor family 1 subfamily J member 4 | ENSG00000239590 | OR1J4 | chr9:122519141-122520082:+ | Tdark | 0 |
| BPI fold containing family A member 3 | ENSG00000131059 | BPIFA3 | chr20:33217310-33227758:+ | Tdark | 0.25 |
| phosphodiesterase 6A | ENSG00000132915 | PDE6A | chr5:149857955-149944793:- | Tclin | 93.3503 |
| thrombospondin type laminin G domain and EAR repeats | ENSG00000175894 | TSPEAR | chr21:44497892-44711580:- | Tbio | 1.5 |
| glutamate decarboxylase like 1 | ENSG00000144644 | GADL1 | chr3:30726200-30894765:- | Tbio | 12.0333 |
| neuropeptides B and W receptor 2 | ENSG00000125522 | NPBWR2 | chr20:64105820-64107171:- | Tbio | 7.23571 |
| G protein-coupled receptor 26 | ENSG00000154478 | GPR26 | chr10:123666355-123694607:+ | Tbio | 6.61215 |
| olfactory receptor family 52 subfamily E member 8 | ENSG00000183269 | OR52E8 | chr11:5856674-5857734:- | Tdark | 0 |
| cation channel sperm associated 3 | ENSG00000152705 | CATSPER3 | chr5:134967906-135011707:+ | Tchem | 5.76154 |
| plasminogen like B2 | ENSG00000125551 | PLGLB2 | chr2:87748087-87758793:+ | Tdark | 15.9936 |
| solute carrier family 7 member 13 | ENSG00000164893 | SLC7A13 | chr8:86214052-86321146:- | Tdark | 8.11666 |
| fibroblast growth factor 16 | ENSG00000196468 | FGF16 | chrX:77447405-77457278:+ | Tbio | 31.1815 |
| olfactory receptor family 11 subfamily H member 1 | ENSG00000130538 | OR11H1 | chr22:15528158-15529139:+ | Tdark | 15.1 |
| ATPase H+/K+ transporting subunit beta | ENSG00000186009 | ATP4B | chr13:113648804-113658186:- | Tclin | 7.11667 |
| serine/threonine kinase like domain containing 1 | ENSG00000198870 | STKLD1 | chr9:133376367-133406096:+ | Tdark | 0 |
| serine protease 56 | ENSG00000237412 | PRSS56 | chr2:232520463-232525716:+ | Tdark | 3 |
| EPH receptor A6 | ENSG00000080224 | EPHA6 | chr3:96814581-97752460:+ | Tchem | 11.0377 |
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