PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
H4 clustered histone 13ENSG00000275126HIST1H4Lchr6:27873199-27873510:-0
cyclic nucleotide gated channel subunit alpha 4ENSG00000132259CNGA4chr11:6234765-6244429:+Tbio6.00952
solute carrier family 17 member 6ENSG00000091664SLC17A6chr11:22338097-22379503:+Tbio92.3845
glycine receptor alpha 3ENSG00000145451GLRA3chr4:174636914-174829314:-Tchem22.075
relaxin family peptide receptor 3ENSG00000182631RXFP3chr5:33936386-33938237:+Tbio32.4948
G protein-coupled receptor 78ENSG00000155269GPR78chr4:8558725-8619761:+Tbio7.49909
fatty acid binding protein 9ENSG00000205186FABP9chr8:81458341-81461579:-Tbio34.1762
olfactory receptor family 4 subfamily K member 17ENSG00000176230OR4K17chr14:20117407-20118438:+Tdark0
ADAM metallopeptidase with thrombospondin type 1 motif 20ENSG00000173157ADAMTS20chr12:43353866-43551921:-Tbio4.4047
olfactory receptor family 2 subfamily C member 1ENSG00000168158OR2C1chr16:3355889-3357294:+Tdark0
MAS related GPR family member X3ENSG00000179826MRGPRX3chr11:18120955-18138480:+Tdark2.84549
potassium voltage-gated channel modifier subfamily V member 1ENSG00000164794KCNV1chr8:109963645-109975847:-Tclin7.41993
nuclear receptor subfamily 2 group E member 3ENSG00000278570NR2E3chr15:71792638-71818259:+Tbio122.81
FKBP prolyl isomerase 6ENSG00000077800FKBP6chr7:73328164-73358637:+Tbio12.8845
BPI fold containing family B member 4ENSG00000186191BPIFB4chr20:33079644-33111751:+Tdark2.53333
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)ENSG00000105371ICAM4chr19:10286967-10288522:+Tbio34.0578
G protein-coupled receptor kinase 7ENSG00000114124GRK7chr3:141778148-141818490:+Tchem7.87976
interferon lambda 2ENSG00000183709IFNL2chr19:39268514-39270092:+Tbio10.7262
chorionic gonadotropin subunit beta 2ENSG00000104818CGB2chr19:49031912-49033238:+Tdark1.16667
aryl hydrocarbon receptor interacting protein like 1ENSG00000129221AIPL1chr17:6393693-6435199:-Tbio79.5763

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