PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
interferon alpha 5ENSG00000147873IFNA5chr9:21304326-21305312:-Tbio28.4399
chloride voltage-gated channel 1ENSG00000188037CLCN1chr7:143316126-143352083:+Tbio273.62
olfactory receptor family 4 subfamily N member 2ENSG00000176294OR4N2chr14:19719015-19828372:+Tdark21.8333
glycophorin E (MNS blood group)ENSG00000197465GYPEchr4:143870867-143905563:-Tdark37.0595
matrix metallopeptidase 23BENSG00000189409MMP23Bchr1:1632095-1701810:+Tbio18.0246
interferon alpha 4ENSG00000236637IFNA4chr9:21186694-21187671:-Tbio24.5477
epididymal protein 3AENSG00000181562EDDM3Achr14:20731699-20748380:+Tdark7.95
lysozyme like 1ENSG00000120563LYZL1chr10:29289061-29318328:+Tdark0.2
protein kinase cAMP-activated catalytic subunit gammaENSG00000165059PRKACGchr9:69012505-69014113:-Tbio6.27165
potassium voltage-gated channel subfamily H member 4ENSG00000089558KCNH4chr17:42156891-42181278:-Tclin20.2012
keratocanENSG00000139330KERAchr12:91050491-91057983:-Tbio44.7632
calcium voltage-gated channel auxiliary subunit gamma 5ENSG00000075429CACNG5chr17:66835117-66885486:+Tdark0.902778
dipeptidase 3ENSG00000141096DPEP3chr16:67975663-67980829:-Tbio0.366667
taste 1 receptor member 1ENSG00000173662TAS1R1chr1:6555181-6579757:+Tbio61.5256
fibroblast growth factor 6ENSG00000111241FGF6chr12:4428155-4445614:-Tbio36.2064
olfactory receptor family 2 subfamily A member 4ENSG00000180658OR2A4chr6:131700469-131701401:-Tdark0.833333
polycystin 2 like 1, transient receptor potential cation channelENSG00000107593PKD2L1chr10:100288154-100330486:-Tbio43.4249
neuropeptide Y receptor Y4ENSG00000204174NPY4Rchr10:46461099-46465881:-Tchem156.664
5-hydroxytryptamine receptor 3CENSG00000178084HTR3Cchr3:184053047-184060671:+Tchem11.5357
olfactory receptor family 5 subfamily I member 1ENSG00000167825OR5I1chr11:55935456-55936400:-Tdark2.375

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