PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
BPI fold containing family A member 2ENSG00000131050BPIFA2chr20:33161768-33181412:+Tbio66.954
olfactory receptor family 14 subfamily A member 16ENSG00000196772OR14A16chr1:247814800-247815729:-Tdark1
Wnt family member 9BENSG00000158955WNT9Bchr17:46833201-46886730:+Tbio18.1041
olfactory receptor family 2 subfamily L member 13ENSG00000196071OR2L13chr1:247937191-248100922:+Tdark0.367857
cytochrome P450 family 2 subfamily F member 1ENSG00000197446CYP2F1chr19:41114432-41128366:+Tbio30.475
glutamate metabotropic receptor 2ENSG00000164082GRM2chr3:51707070-51718613:+Tchem35.4237
tubulin beta 8 class VIIIENSG00000261456TUBB8chr10:46892-74163:-Tclin1
translocator protein 2ENSG00000112212TSPO2chr6:41042554-41044337:+Tdark2.13333
corticotropin releasing hormone receptor 2ENSG00000106113CRHR2chr7:30651943-30700129:-Tchem150.987
polycystin 2 like 2, transient receptor potential cation channelENSG00000078795PKD2L2chr5:137887968-137942747:+Tdark2.99166
leucine rich repeat, Ig-like and transmembrane domains 2ENSG00000204033LRIT2chr10:84220495-84225589:-Tdark0
netrin 3ENSG00000162068NTN3chr16:2471499-2474145:+Tdark4.71154
free fatty acid receptor 3ENSG00000185897FFAR3chr19:35358460-35360485:+Tbio34.6084
ATP binding cassette subfamily A member 10ENSG00000154263ABCA10chr17:69147214-69244846:-Tdark2.44708
trace amine associated receptor 8ENSG00000146385TAAR8chr6:132552693-132553721:+Tbio10.2955
interferon alpha 10ENSG00000186803IFNA10chr9:21206181-21207143:-Tbio16.3353
peptidylprolyl isomerase A like 4CENSG00000263464PPIAL4Cchr1:149583865-149584464:+Tdark0
SVOP likeENSG00000157703SVOPLchr7:138594285-138701352:-Tdark0.658333
solute carrier family 6 member 5ENSG00000165970SLC6A5chr11:20599400-20659285:+Tchem38.4519
otogelinENSG00000188162OTOGchr11:17547373-17647150:+Tdark11.0409

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