PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
chymotrypsinogen B2ENSG00000168928CTRB2chr16:75204096-75207185:-Tchem8.03218
ribonuclease A family member 10 (inactive)ENSG00000182545RNASE10chr14:20505537-20511169:+Tdark0.25
transglutaminase 6ENSG00000166948TGM6chr20:2380908-2432753:+Tchem31.1619
interferon alpha 21ENSG00000137080IFNA21chr9:21165637-21166660:-Tbio10.9635
gamma-aminobutyric acid type A receptor subunit rho1ENSG00000146276GABRR1chr6:89177501-89231278:-Tchem30.265
myosin light chain kinase 3ENSG00000140795MYLK3chr16:46703369-46790407:-Tchem84.0718
G protein-coupled receptor 32ENSG00000142511GPR32chr19:50770464-50771732:+Tbio7.11905
potassium two pore domain channel subfamily K member 16ENSG00000095981KCNK16chr6:39314698-39322968:-Tdark5.01069
hypocretin receptor 2ENSG00000137252HCRTR2chr6:55106460-55282620:+Tclin71.1857
olfactory receptor family 8 subfamily D member 4ENSG00000181518OR8D4chr11:123906146-123907476:+Tdark0
laeverinENSG00000172901LVRNchr5:115962454-116027619:+Tbio15.3646
solute carrier family 4 member 9ENSG00000113073SLC4A9chr5:140360202-140375143:+Tbio10.8357
G protein-coupled receptor 12ENSG00000132975GPR12chr13:26755200-26760785:-Tbio8.2381
olfactory receptor family 2 subfamily L member 3ENSG00000198128OR2L3chr1:248060682-248061620:+Tdark0
histatin 1ENSG00000126550HTN1chr4:70050402-70058845:+Tbio92.6583
UDP glucuronosyltransferase family 1 member A8ENSG00000242366UGT1A8chr2:233617645-233773310:+Tbio62.9186
parathyroid hormone 2ENSG00000142538PTH2chr19:49422414-49423441:-Tdark34.4576
kelch like family member 10ENSG00000161594KLHL10chr17:41835685-41848384:+Tdark5.86667
integrin subunit alpha DENSG00000156886ITGADchr16:31393312-31426505:+Tbio17.4991
trace amine associated receptor 2ENSG00000146378TAAR2chr6:132617022-132624275:-Tbio12.2917

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