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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
olfactory receptor family 10 subfamily G member 8	ENSG00000234560	OR10G8	chr11:124029590-124030634:+	Tdark	0
neuromedin S	ENSG00000204640	NMS	chr2:100470482-100483280:+	Tbio	9.075
BPI fold containing family C	ENSG00000184459	BPIFC	chr22:32413847-32464484:-	Tdark	0.783333
olfactory receptor family 10 subfamily K member 1	ENSG00000173285	OR10K1	chr1:158465562-158466503:+	Tdark	172.826
TAFA chemokine like family member 1	ENSG00000183662	FAM19A1	chr3:68004216-68545625:+	Tdark	0.4
interleukin 22 receptor subunit alpha 2	ENSG00000164485	IL22RA2	chr6:137143820-137173648:-	Tbio	13.4899
phospholipase A2 group IVD	ENSG00000159337	PLA2G4D	chr15:42067009-42094554:-	Tbio	3.03155
insulin like 4	ENSG00000120211	INSL4	chr9:5231419-5235304:+	Tbio	25.284
solute carrier family 32 member 1	ENSG00000101438	SLC32A1	chr20:38724462-38729372:+	Tbio	45.9771
transient receptor potential cation channel subfamily M member 5	ENSG00000070985	TRPM5	chr11:2404515-2423045:-	Tbio	46.6357
galanin receptor 2	ENSG00000182687	GALR2	chr17:76074794-76077541:+	Tchem	51.1575
WEE2 oocyte meiosis inhibiting kinase	ENSG00000214102	WEE2	chr7:141708353-141731271:+	Tbio	5.225
glycophorin B (MNS blood group)	ENSG00000250361	GYPB	chr4:143996104-144019345:-	Tbio	27.8333
fructose-bisphosphatase 2	ENSG00000130957	FBP2	chr9:94558720-94593793:-	Tbio	47.9878
butyrophilin subfamily 2 member A1	ENSG00000112763	BTN2A1	chr6:26457904-26476621:+	Tbio	23.2387
phosphodiesterase 6C	ENSG00000095464	PDE6C	chr10:93612588-93666010:+	Tclin	19.6069
GDNF family receptor alpha 4	ENSG00000125861	GFRA4	chr20:3659292-3663399:-	Tdark	6.3369
ATP binding cassette subfamily C member 12	ENSG00000140798	ABCC12	chr16:48082973-48156018:-	Tbio	9.08364
G protein-coupled receptor 139	ENSG00000180269	GPR139	chr16:20031485-20073917:-	Tchem	10.323
acid sensing ion channel subunit family member 5	ENSG00000256394	ASIC5	chr4:155829729-155866273:-	Tbio	6.33333

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