PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
potassium voltage-gated channel modifier subfamily G member 2ENSG00000178342KCNG2chr18:79863668-79900184:+Tclin2.02592
thioredoxin domain containing 2ENSG00000168454TXNDC2chr18:9885726-9889275:+Tbio6.05498
zona pellucida glycoprotein 2ENSG00000103310ZP2chr16:21197450-21214510:-Tbio64.6782
contactin associated protein family member 3BENSG00000154529CNTNAP3Bchr9:41890314-42129510:-Tdark0
olfactory receptor family 10 subfamily K member 2ENSG00000180708OR10K2chr1:158419928-158420866:-Tdark170.393
H3 clustered histone 12ENSG00000197153HIST1H3Jchr6:27890382-27893106:-0
5-hydroxytryptamine receptor 4ENSG00000164270HTR4chr5:148451032-148677235:-Tclin116.616
zona pellucida glycoprotein 4ENSG00000116996ZP4chr1:237877864-237890922:-Tbio48.2959
chymotrypsinogen B1ENSG00000168925CTRB1chr16:75219000-75224924:+Tchem8.03218
ATP/GTP binding protein like 4ENSG00000186094AGBL4chr1:48532855-50023913:-Tbio2.75
ADAM metallopeptidase with thrombospondin type 1 motif 18ENSG00000140873ADAMTS18chr16:77247813-77435114:-Tbio36.858
stromal cell derived factor 2ENSG00000132581SDF2chr17:28648356-28662189:-Tbio6.52424
solute carrier family 5 member 7ENSG00000115665SLC5A7chr2:107986523-108013994:+Tchem95.8437
glutamate metabotropic receptor 7ENSG00000196277GRM7chr3:6770001-7741533:+Tbio46.2683
bromodomain containing 2ENSG00000204256BRD2chr6:32968660-32981505:+Tchem345.741
solute carrier family 25 member 36ENSG00000114120SLC25A36chr3:140941830-140979933:+Tbio11.5028
calcitonin related polypeptide betaENSG00000175868CALCBchr11:14904997-15082342:+Tbio55.3162
synaptic vesicle glycoprotein 2CENSG00000122012SV2Cchr5:76083172-76353939:+Tbio14.0532
sialic acid binding Ig like lectin 5ENSG00000105501SIGLEC5chr19:51611503-51645545:-Tbio31.8086
tubulin alpha 3cENSG00000198033TUBA3Cchr13:19173770-19181852:-Tchem7.75

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