PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| VRK serine/threonine kinase 3 | ENSG00000105053 | VRK3 | chr19:49976467-50025946:- | Tbio | 3.375 |
| defensin alpha 3 | ENSG00000239839 | DEFA3 | chr8:6996837-7018301:- | Tbio | 83.2653 |
| olfactory receptor family 1 subfamily F member 1 | ENSG00000168124 | OR1F1 | chr16:3204247-3205188:+ | Tdark | 1.1 |
| poly(ADP-ribose) polymerase family member 16 | ENSG00000138617 | PARP16 | chr15:65234460-65300618:- | Tbio | 35.3929 |
| kallikrein related peptidase 9 | ENSG00000213022 | KLK9 | chr19:51003111-51009634:- | Tbio | 4.63761 |
| CEA cell adhesion molecule 8 | ENSG00000124469 | CEACAM8 | chr19:42580241-42740384:- | Tbio | 155.419 |
| calcium voltage-gated channel subunit alpha1 F | ENSG00000102001 | CACNA1F | chrX:49205063-49233371:- | Tchem | 137.807 |
| ATPase Na+/K+ transporting subunit alpha 4 | ENSG00000132681 | ATP1A4 | chr1:160151570-160186977:+ | Tclin | 5.01667 |
| G protein-coupled receptor 182 | ENSG00000166856 | GPR182 | chr12:56994446-56998441:+ | Tbio | 41.3159 |
| TNNI3 interacting kinase | ENSG00000116783 | TNNI3K | chr1:74235401-74544428:+ | Tchem | 17.636 |
| submaxillary gland androgen regulated protein 3B | ENSG00000171201 | SMR3B | chr4:70370093-70390244:+ | Tdark | 186.159 |
| cyclin B3 | ENSG00000147082 | CCNB3 | chrX:50202713-50351910:+ | Tbio | 15.231 |
| angiopoietin like 5 | ENSG00000187151 | ANGPTL5 | chr11:101890674-101916522:- | Tdark | 4.43347 |
| pregnancy specific beta-1-glycoprotein 2 | ENSG00000242221 | PSG2 | chr19:43064211-43083045:- | Tbio | 2.13254 |
| interleukin 31 | ENSG00000204671 | IL31 | chr12:122172030-122174199:- | Tbio | 107.106 |
| natural cytotoxicity triggering receptor 2 | ENSG00000096264 | NCR2 | chr6:41335655-41350887:+ | Tbio | 19.0833 |
| G protein-coupled receptor 55 | ENSG00000135898 | GPR55 | chr2:230907318-230961066:- | Tchem | 127.891 |
| FKBP prolyl isomerase 8 | ENSG00000105701 | FKBP8 | chr19:18531751-18544077:- | Tbio | 44.2377 |
| neuropeptide Y receptor Y2 | ENSG00000185149 | NPY2R | chr4:155208629-155217078:+ | Tchem | 56.8738 |
| cystatin 9 | ENSG00000173335 | CST9 | chr20:23602410-23605876:- | Tdark | 7.75 |
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