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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
matrix metallopeptidase 21	ENSG00000154485	MMP21	chr10:125766453-125775821:-	Tbio	20.8645
potassium voltage-gated channel subfamily A member 10	ENSG00000143105	KCNA10	chr1:110517251-110518838:-	Tclin	8.73501
cerberus 1, DAN family BMP antagonist	ENSG00000147869	CER1	chr9:14719724-14722717:-	Tbio	30.447
potassium voltage-gated channel subfamily A member 7	ENSG00000104848	KCNA7	chr19:49067418-49072941:-	Tclin	7.45168
calpain 11	ENSG00000137225	CAPN11	chr6:44158811-44184402:+	Tdark	2.27143
MAS related GPR family member D	ENSG00000172938	MRGPRD	chr11:68980021-68980986:-	Tbio	9.70278
membrane bound O-acyltransferase domain containing 4	ENSG00000177669	MBOAT4	chr8:30131824-30144686:-	Tbio	8.52424
TAP binding protein like	ENSG00000139192	TAPBPL	chr12:6451690-6466517:+	Tbio	7.46212
interleukin 36 beta	ENSG00000136696	IL36B	chr2:113022091-113052867:-	Tbio	9.15339
interleukin 25	ENSG00000166090	IL25	chr14:23372809-23376403:+	Tbio	102.222
olfactory receptor family 7 subfamily A member 17	ENSG00000185385	OR7A17	chr19:14880426-14881452:-	Tdark	0
UDP glucuronosyltransferase family 2 member B28	ENSG00000135226	UGT2B28	chr4:69280487-69423402:+	Tbio	8.73333
taste 2 receptor member 60	ENSG00000185899	TAS2R60	chr7:143443453-143444409:+	Tbio	0.416667
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2	ENSG00000139613	SMARCC2	chr12:56162983-56189567:-	Tbio	11.4199
TATA-box binding protein associated factor 1 like	ENSG00000122728	TAF1L	chr9:32629454-32635669:-	Tchem	0.333333
interleukin 19	ENSG00000142224	IL19	chr1:206798870-206842981:+	Tbio	100.605
tolloid like 2	ENSG00000095587	TLL2	chr10:96364606-96513918:-	Tbio	5.47619
semenogelin 1	ENSG00000124233	SEMG1	chr20:45206997-45209772:+	Tbio	28
trace amine associated receptor 9	ENSG00000237110	TAAR9	chr6:132538290-132539336:+	Tdark	54.9996
chymotrypsin like elastase 3A	ENSG00000142789	CELA3A	chr1:22001656-22012539:+	Tbio	1

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