PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| immunoglobulin lambda variable 10-54 | ENSG00000211642 | IGLV10-54 | chr22:22214794-22215270:+ | Tdark | 0 |
| G protein-coupled receptor 150 | ENSG00000178015 | GPR150 | chr5:95620078-95622142:+ | Tdark | 0.680158 |
| immunoglobulin kappa variable 1-5 | ENSG00000243466 | IGKV1-5 | chr2:88947301-88947957:- | Tdark | 2.5 |
| immunoglobulin heavy constant gamma 4 (G4m marker) | ENSG00000211892 | IGHG4 | chr14:105624341-105626066:- | Tbio | 1 |
| immunoglobulin heavy constant gamma 2 (G2m marker) | ENSG00000211893 | IGHG2 | chr14:105643052-105644790:- | Tbio | 0 |
| purinergic receptor P2X 3 | ENSG00000109991 | P2RX3 | chr11:57338374-57370600:+ | Tchem | 139.293 |
| olfactomedin 3 | ENSG00000118733 | OLFM3 | chr1:101802574-101997030:- | Tbio | 5.38571 |
| immunoglobulin heavy variable 3-23 | ENSG00000211949 | IGHV3-23 | chr14:106268606-106269140:- | Tdark | 0 |
| ADAM metallopeptidase domain 7 | ENSG00000069206 | ADAM7 | chr8:24440930-24526970:+ | Tdark | 18.7929 |
| V-set and transmembrane domain containing 1 | ENSG00000189068 | VSTM1 | chr19:54040825-54063953:- | Tbio | 10.9333 |
| immunoglobulin lambda constant 3 (Kern-Oz+ marker) | ENSG00000211679 | IGLC3 | chr22:22906342-22906803:+ | Tdark | 0 |
| immunoglobulin lambda variable 7-46 | ENSG00000211649 | IGLV7-46 | chr22:22369614-22370087:+ | Tdark | 0 |
| bone morphogenetic protein 15 | ENSG00000130385 | BMP15 | chrX:50910784-50916607:+ | Tbio | 112.671 |
| matrix extracellular phosphoglycoprotein | ENSG00000152595 | MEPE | chr4:87821411-87846817:+ | Tbio | 73.8931 |
| immunoglobulin kappa variable 3-20 | ENSG00000239951 | IGKV3-20 | chr2:89142574-89143160:- | Tbio | 0.5 |
| immunoglobulin lambda constant 2 | ENSG00000211677 | IGLC2 | chr22:22900976-22901437:+ | Tdark | 0 |
| hyperpolarization activated cyclic nucleotide gated potassium channel 4 | ENSG00000138622 | HCN4 | chr15:73319859-73369264:- | Tclin | 149.95 |
| cyclic nucleotide gated channel subunit beta 3 | ENSG00000170289 | CNGB3 | chr8:86553977-86743675:- | Tbio | 50.2383 |
| ATP23 metallopeptidase and ATP synthase assembly factor homolog | ENSG00000166896 | XRCC6BP1 | chr12:57941541-57957269:+ | Tdark | 5.02512 |
| ring finger and SPRY domain containing 1 | ENSG00000159579 | RSPRY1 | chr16:57186137-57240475:+ | Tdark | 0 |
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