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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
immunoglobulin kappa variable 3-11	ENSG00000241351	IGKV3-11	chr2:88857361-89027731:-	Tdark	0
immunoglobulin lambda variable 1-44	ENSG00000211651	IGLV1-44	chr22:22380766-22381347:+	Tdark	0
potassium sodium-activated channel subfamily T member 1	ENSG00000107147	KCNT1	chr9:135702185-135795508:+	Tchem	46.3266
solute carrier family 39 member 9	ENSG00000029364	SLC39A9	chr14:69398015-69462388:+	Tbio	8.58514
immunoglobulin kappa variable 3-15	ENSG00000244437	IGKV3-15	chr2:89085177-89085787:-	Tdark	0
immunoglobulin lambda variable 2-23	ENSG00000211660	IGLV2-23	chr22:22697789-22698407:+	Tdark	0
interferon alpha 6	ENSG00000120235	IFNA6	chr9:21349835-21351378:-	Tbio	14.4427
immunoglobulin lambda variable 1-40	ENSG00000211653	IGLV1-40	chr22:22409766-22410282:+	Tdark	0
opsin 4	ENSG00000122375	OPN4	chr10:86654557-86666848:+	Tbio	38.7855
immunoglobulin lambda variable 2-11	ENSG00000211668	IGLV2-11	chr22:22792491-22793007:+	Tdark	0
major facilitator superfamily domain containing 9	ENSG00000135953	MFSD9	chr2:102715840-102736888:-	Tdark	0.276923
tubulin alpha 3e	ENSG00000152086	TUBA3E	chr2:130191743-130198461:-	Tchem	0.03125
immunoglobulin lambda variable 4-69	ENSG00000211637	IGLV4-69	chr22:22030934-22031472:+	Tdark	0
H3 clustered histone 1	ENSG00000275714	HIST1H3A	chr6:26020490-26020900:+		0
immunoglobulin lambda variable 7-43	ENSG00000211652	IGLV7-43	chr22:22395018-22395489:+	Tdark	0
immunoglobulin heavy variable 1-46	ENSG00000211962	IGHV1-46	chr14:106511117-106511856:-	Tdark	0
immunoglobulin heavy constant gamma 1 (G1m marker)	ENSG00000211896	IGHG1	chr14:105668113-106538344:-	Tbio	3.5
syncollin	ENSG00000179751	SYCN	chr19:39202831-39204266:-	Tdark	8.7
immunoglobulin kappa variable 4-1	ENSG00000211598	IGKV4-1	chr2:88885397-88886153:+	Tdark	2.45
immunoglobulin lambda variable 1-51	ENSG00000211644	IGLV1-51	chr22:22322472-22322980:+	Tdark	0

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