PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
serine/threonine kinase 16ENSG00000115661STK16chr2:219245455-219250337:+Tchem19.4345
protease associated domain containing 1ENSG00000135617PRADC1chr2:73228006-73233238:-Tdark2.34091
immunoglobulin kappa variable 2D-29ENSG00000243264IGKV2D-29chr2:89947512-89948279:+Tdark0
solute carrier family 22 member 8ENSG00000149452SLC22A8chr11:62989154-63015839:-Tclin122.059
gamma-aminobutyric acid type A receptor subunit rho2ENSG00000111886GABRR2chr6:89257208-89315299:-Tbio7.02406
PZP alpha-2-macroglobulin likeENSG00000126838PZPchr12:9148840-9208370:-Tbio74.2966
immunoglobulin lambda variable 5-45ENSG00000211650IGLV5-45chr22:22375986-22376505:+Tdark0
UDP glucuronosyltransferase family 1 member A3ENSG00000243135UGT1A3chr2:233729108-233773299:+Tbio84.1425
serpin family B member 10ENSG00000242550SERPINB10chr18:63897174-63936111:+Tbio26.1243
ATP binding cassette subfamily G member 4ENSG00000172350ABCG4chr11:119149012-119162653:+Tbio23.1754
glycoprotein Ib platelet subunit betaENSG00000203618GP1BBchr22:19722945-19724771:+Tbio57.6794
defensin beta 103BENSG00000177243DEFB103Bchr8:7428888-7430348:-Tbio259.69
urotensin 2ENSG00000049247UTS2chr1:7843083-7853512:-Tbio375.756
Josephin domain containing 1ENSG00000100221JOSD1chr22:38685543-38701556:-Tdark0.799242
interferon lambda 1ENSG00000182393IFNL1chr19:39296325-39298673:+Tbio28.8095
immunoglobulin heavy variable 1-2ENSG00000211934IGHV1-2chr14:105986582-105987083:-Tdark0
serine/threonine/tyrosine interacting proteinENSG00000198252STYXchr14:52730180-52774998:+Tbio18.625
immunoglobulin lambda variable 3-25ENSG00000211659IGLV3-25chr22:22686726-22687271:+Tdark0
PR/SET domain 12ENSG00000130711PRDM12chr9:130664594-130682981:+Tbio7.41667
glucagon like peptide 2 receptorENSG00000065325GLP2Rchr17:9822206-9892102:+Tclin29.8353

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