Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 300 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| TPH2 | ENSG00000139287 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.22 | 0.03 | 0.00 | 0.00 | 0.03 | 0.02 | 0.13 | 0.02 | 0.14 | 0.02 | 0.11 | 0.02 | 0.22 | 0.03 | 0.13 | 0.02 | 0.00 | 0.01 | 0.04 | 0.04 | 0.05 | 0.03 | 0.03 | 0.01 | 0.00 | 0.05 | 0.30 | 0.02 | 0.06 | 0.02 | 0.00 | 0.00 | 0.23 | 0.02 | 0.24 | 0.06 | 0.06 | 0.01 | 0.05 | 0.02 | 0.18 | 0.09 | 0.64 | 0.04 | 0.27 | 0.00 | 0.00 | 0.00 | 0.18 | 0.00 | 0.01 | 0.01 | 0.08 | 0.03 | 0.00 | 0.00 | 0.14 | 0.03 |
| KCNH7 | ENSG00000184611 | 0.02 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.02 | 0.10 | 0.09 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.07 | 0.01 | 0.10 | 0.03 | 0.06 | 0.02 | 0.10 | 0.03 | 0.03 | 0.04 | 0.01 | 0.02 | 0.01 | 0.02 | 0.05 | 0.01 | 0.05 | 0.06 | 0.00 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.03 | 0.32 | 0.04 | 0.06 | 0.01 | 0.04 | 0.01 | 0.03 | 0.00 | 0.06 | 0.08 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.15 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.02 |
| PM20D1 | ENSG00000162877 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.02 | 0.06 | 0.06 | 0.01 | 0.00 | 0.10 | 0.00 | 0.12 | 0.01 | 0.09 | 0.01 | 0.05 | 0.00 | 0.17 | 0.07 | 0.06 | 0.02 | 0.04 | 0.00 | 0.12 | 0.02 | 0.00 | 0.00 | 0.19 | 0.01 | 0.18 | 0.02 | 0.03 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.28 | 0.01 | 0.28 | 0.09 | 0.07 | 0.00 | 0.14 | 0.01 | 0.26 | 0.04 | 0.05 | 0.17 | 0.05 | 0.02 | 0.01 | 0.00 | 0.21 | 0.04 | 0.00 | 0.01 | 0.05 | 0.02 | 0.09 | 0.00 | 0.17 | 0.02 |
| FBP2 | ENSG00000130957 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.05 | 0.04 | 0.00 | 0.01 | 0.01 | 0.04 | 0.01 | 0.05 | 0.04 | 0.02 | 0.04 | 0.00 | 0.06 | 0.02 | 0.02 | 0.04 | 0.01 | 0.01 | 0.04 | 0.02 | 0.01 | 0.01 | 0.03 | 0.04 | 0.00 | 0.08 | 0.04 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.03 | 0.07 | 0.14 | 0.02 | 0.02 | 0.01 | 0.05 | 0.00 | 0.11 | 0.10 | 0.01 | 0.04 | 0.02 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 |
| GLRA2 | ENSG00000101958 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.06 | 0.03 | 0.00 | 0.00 | 0.00 | 0.05 | 0.02 | 0.05 | 0.09 | 0.05 | 0.03 | 0.02 | 0.06 | 0.03 | 0.05 | 0.02 | 0.01 | 0.01 | 0.13 | 0.02 | 0.00 | 0.01 | 0.03 | 0.02 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.06 | 0.03 | 0.13 | 0.17 | 0.05 | 0.01 | 0.03 | 0.02 | 0.06 | 0.10 | 0.14 | 0.05 | 0.06 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.02 |
| TSPEAR | ENSG00000175894 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 | 0.06 | 0.05 | 0.00 | 0.02 | 0.00 | 0.01 | 0.03 | 0.03 | 0.03 | 0.06 | 0.02 | 0.06 | 0.05 | 0.08 | 0.02 | 0.07 | 0.02 | 0.03 | 0.02 | 0.06 | 0.01 | 0.01 | 0.03 | 0.02 | 0.05 | 0.07 | 0.09 | 0.05 | 0.01 | 0.00 | 0.00 | 0.00 | 0.10 | 0.02 | 0.20 | 0.18 | 0.07 | 0.04 | 0.05 | 0.02 | 0.10 | 0.14 | 0.08 | 0.10 | 0.04 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.02 | 0.03 | 0.06 | 0.00 | 0.02 | 0.03 |
| ADAMTS20 | ENSG00000173157 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.08 | 0.04 | 0.00 | 0.00 | 0.02 | 0.07 | 0.07 | 0.04 | 0.05 | 0.02 | 0.02 | 0.03 | 0.05 | 0.06 | 0.09 | 0.05 | 0.01 | 0.01 | 0.01 | 0.04 | 0.01 | 0.04 | 0.02 | 0.01 | 0.00 | 0.01 | 0.18 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.07 | 0.04 | 0.23 | 0.06 | 0.02 | 0.00 | 0.05 | 0.01 | 0.19 | 0.08 | 0.18 | 0.08 | 0.00 | 0.02 | 0.00 | 0.01 | 0.05 | 0.00 | 0.03 | 0.06 | 0.06 | 0.07 | 0.00 | 0.00 | 0.07 | 0.06 |
| PRSS55 | ENSG00000184647 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.01 | 0.01 | 0.14 | 0.02 | 0.13 | 0.00 | 0.00 | 0.02 | 0.03 | 0.03 | 0.06 | 0.02 | 0.12 | 0.00 | 0.08 | 0.31 | 0.06 | 0.28 | 0.02 | 0.01 | 0.09 | 0.00 | 0.20 | 0.03 | 0.05 | 0.01 | 0.11 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.03 | 0.15 | 0.03 | 0.41 | 0.01 | 0.06 | 0.01 | 0.09 | 0.10 | 0.24 | 0.06 | 0.09 | 0.02 | 0.01 | 0.00 | 0.00 | 0.04 | 0.06 | 0.00 | 0.01 | 0.02 | 0.02 | 0.00 | 0.01 | 0.02 | 0.04 |
| GRM7 | ENSG00000196277 | 0.00 | 0.18 | 0.00 | 0.01 | 0.07 | 0.03 | 0.01 | 0.04 | 0.35 | 0.05 | 0.00 | 0.06 | 0.03 | 0.12 | 0.04 | 0.05 | 0.03 | 0.05 | 0.04 | 0.04 | 0.05 | 0.08 | 0.03 | 0.10 | 0.00 | 0.06 | 0.01 | 0.06 | 0.01 | 0.02 | 0.06 | 0.02 | 0.00 | 0.18 | 0.07 | 0.01 | 0.00 | 0.04 | 0.00 | 0.00 | 0.13 | 0.03 | 0.15 | 0.22 | 0.03 | 0.01 | 0.04 | 0.04 | 0.05 | 0.16 | 0.27 | 0.05 | 0.05 | 0.05 | 0.00 | 0.00 | 0.00 | 0.05 | 0.03 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.02 | 0.06 |
| FGF3 | ENSG00000186895 | 0.01 | 0.01 | 0.03 | 0.01 | 0.09 | 0.00 | 0.09 | 0.00 | 0.78 | 0.01 | 0.00 | 0.00 | 0.08 | 0.00 | 0.20 | 0.00 | 1.10 | 0.01 | 1.98 | 0.00 | 2.81 | 0.00 | 0.41 | 0.02 | 0.02 | 0.01 | 0.09 | 0.02 | 0.04 | 0.01 | 0.38 | 0.01 | 0.50 | 0.02 | 0.03 | 0.01 | 0.02 | 0.00 | 0.00 | 0.00 | 1.24 | 0.02 | 0.43 | 0.03 | 0.30 | 0.03 | 0.16 | 0.02 | 0.17 | 0.11 | 0.20 | 0.05 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.00 | 0.40 | 0.01 |
| GP5 | ENSG00000178732 | 0.05 | 0.00 | 0.03 | 0.01 | 0.00 | 0.01 | 0.02 | 0.05 | 0.17 | 0.02 | 0.00 | 0.00 | 0.00 | 0.04 | 0.14 | 0.06 | 1.35 | 0.01 | 0.57 | 0.00 | 0.76 | 0.02 | 0.24 | 0.02 | 0.05 | 0.01 | 0.06 | 0.01 | 0.03 | 0.01 | 0.12 | 0.03 | 0.18 | 0.03 | 0.10 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.21 | 0.02 | 0.99 | 0.08 | 0.65 | 0.00 | 0.37 | 0.00 | 0.80 | 0.15 | 0.12 | 0.10 | 0.16 | 0.02 | 0.00 | 0.00 | 0.07 | 0.01 | 0.02 | 0.05 | 0.07 | 0.09 | 0.00 | 0.00 | 0.03 | 0.03 |
| CACNA1S | ENSG00000081248 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.11 | 0.06 | 0.02 | 0.00 | 0.10 | 0.00 | 0.12 | 0.00 | 0.08 | 0.01 | 0.05 | 0.01 | 0.13 | 0.06 | 0.04 | 0.01 | 0.04 | 0.00 | 0.06 | 0.05 | 0.00 | 0.00 | 0.17 | 0.01 | 0.18 | 0.02 | 0.06 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.23 | 0.00 | 0.29 | 0.06 | 0.07 | 0.00 | 0.08 | 0.02 | 0.12 | 0.03 | 0.09 | 0.12 | 0.07 | 0.02 | 0.01 | 0.00 | 0.26 | 0.02 | 0.01 | 0.01 | 0.04 | 0.01 | 0.06 | 0.00 | 0.19 | 0.01 |
| METTL21C | ENSG00000139780 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.18 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.11 | 0.04 | 0.10 | 0.04 | 0.11 | 0.01 | 0.08 | 0.05 | 0.13 | 0.03 | 0.09 | 0.01 | 0.12 | 0.01 | 0.01 | 0.01 | 0.25 | 0.01 | 0.10 | 0.01 | 0.03 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.13 | 0.04 | 0.21 | 0.09 | 0.20 | 0.02 | 0.06 | 0.02 | 0.33 | 0.05 | 0.21 | 0.11 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.10 | 0.03 | 0.03 | 0.05 | 0.02 | 0.05 | 0.00 | 0.06 | 0.05 |
| MRGPRX3 | ENSG00000179826 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.01 | 0.01 | 0.02 | 0.07 | 0.00 | 0.00 | 0.02 | 0.03 | 0.03 | 0.04 | 0.06 | 0.07 | 0.01 | 0.05 | 0.05 | 0.03 | 0.02 | 0.02 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.02 | 0.04 | 0.02 | 0.03 | 0.01 | 0.00 | 0.02 | 0.06 | 0.04 | 0.00 | 0.00 | 0.06 | 0.05 | 0.04 | 0.24 | 0.01 | 0.04 | 0.03 | 0.04 | 0.01 | 0.04 | 0.05 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 |
| WFIKKN2 | ENSG00000173714 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.15 | 0.01 | 0.01 | 0.00 | 0.09 | 0.00 | 0.10 | 0.01 | 0.12 | 0.01 | 0.02 | 0.01 | 0.18 | 0.00 | 0.13 | 0.01 | 0.03 | 0.00 | 0.07 | 0.04 | 0.06 | 0.02 | 0.13 | 0.01 | 0.02 | 0.01 | 0.06 | 0.03 | 0.02 | 0.03 | 0.00 | 0.00 | 0.50 | 0.02 | 0.16 | 0.02 | 0.05 | 0.00 | 0.12 | 0.02 | 0.45 | 0.00 | 0.13 | 0.02 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.04 | 0.00 | 0.03 | 0.03 | 0.16 | 0.01 |
| CA6 | ENSG00000131686 | 0.00 | 0.06 | 0.01 | 0.08 | 0.00 | 0.00 | 0.01 | 0.07 | 0.09 | 0.08 | 0.00 | 0.02 | 0.04 | 0.27 | 0.06 | 0.06 | 0.06 | 0.11 | 0.05 | 0.08 | 0.11 | 0.09 | 0.10 | 0.08 | 0.02 | 0.14 | 0.01 | 0.21 | 0.05 | 0.07 | 0.03 | 0.29 | 0.00 | 1.10 | 0.06 | 0.23 | 0.01 | 0.11 | 0.00 | 0.00 | 0.03 | 0.19 | 0.24 | 0.36 | 0.04 | 0.10 | 0.09 | 0.11 | 0.01 | 0.27 | 0.18 | 0.22 | 0.08 | 0.11 | 0.02 | 0.01 | 0.00 | 0.07 | 0.00 | 0.06 | 0.02 | 0.28 | 0.00 | 0.07 | 0.06 | 0.12 |
| TAS1R1 | ENSG00000173662 | 0.00 | 0.06 | 0.01 | 0.09 | 0.00 | 0.00 | 0.01 | 0.05 | 0.10 | 0.08 | 0.00 | 0.02 | 0.04 | 0.31 | 0.07 | 0.05 | 0.09 | 0.11 | 0.06 | 0.08 | 0.18 | 0.07 | 0.10 | 0.09 | 0.02 | 0.14 | 0.00 | 0.20 | 0.04 | 0.06 | 0.03 | 0.31 | 0.00 | 1.09 | 0.03 | 0.23 | 0.01 | 0.11 | 0.00 | 0.00 | 0.03 | 0.19 | 0.27 | 0.34 | 0.06 | 0.10 | 0.07 | 0.11 | 0.08 | 0.27 | 0.17 | 0.24 | 0.08 | 0.12 | 0.02 | 0.01 | 0.00 | 0.15 | 0.00 | 0.06 | 0.03 | 0.28 | 0.00 | 0.05 | 0.07 | 0.13 |
| TMPRSS15 | ENSG00000154646 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.04 | 0.09 | 0.05 | 0.00 | 0.00 | 0.01 | 0.02 | 0.07 | 0.07 | 0.13 | 0.07 | 0.04 | 0.05 | 0.04 | 0.11 | 0.02 | 0.07 | 0.01 | 0.06 | 0.04 | 0.11 | 0.00 | 0.03 | 0.01 | 0.03 | 0.00 | 0.03 | 0.10 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.09 | 0.17 | 0.12 | 0.02 | 0.05 | 0.03 | 0.02 | 0.04 | 0.20 | 0.14 | 0.10 | 0.01 | 0.00 | 0.04 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.03 | 0.03 | 0.05 | 0.00 | 0.04 | 0.02 |
| TRPM6 | ENSG00000119121 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 | 0.03 | 0.06 | 0.00 | 0.01 | 0.02 | 0.06 | 0.01 | 0.05 | 0.05 | 0.05 | 0.00 | 0.03 | 0.08 | 0.03 | 0.04 | 0.05 | 0.01 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.15 | 0.04 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.04 | 0.11 | 0.16 | 0.02 | 0.02 | 0.02 | 0.04 | 0.00 | 0.23 | 0.14 | 0.01 | 0.02 | 0.03 | 0.00 | 0.02 | 0.05 | 0.09 | 0.00 | 0.01 | 0.01 | 0.04 | 0.00 | 0.00 | 0.02 | 0.03 |
| TTN | ENSG00000155657 | 0.02 | 0.01 | 0.08 | 0.01 | 0.00 | 0.00 | 0.01 | 0.08 | 0.06 | 0.05 | 0.00 | 0.00 | 0.00 | 0.02 | 0.07 | 0.01 | 0.20 | 0.02 | 0.15 | 0.01 | 0.17 | 0.03 | 0.05 | 0.04 | 0.01 | 0.02 | 0.03 | 0.02 | 0.03 | 0.01 | 0.08 | 0.04 | 0.05 | 0.01 | 0.05 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.02 | 0.41 | 0.05 | 0.13 | 0.02 | 0.06 | 0.01 | 0.03 | 0.00 | 0.03 | 0.10 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 |
|
Showing page 300 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.