Mutation

 

The putative cancer-causing GESPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the recurrent mutated GESPs in each cancer type


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 HGNC Name  Ensembl Gene ID  HGNC Symbol  Genomic Location  ACC_Mut%  BLCA_Mut%  BRCA_Mut%  CESC_Mut%  CHOL_Mut%  COAD_Mut%  DLBC_Mut%  ESCA_Mut%  GBM_Mut%  HNSC_Mut%  KICH_Mut%  KIRC_Mut%  KIRP_Mut%  LAML_Mut%  LGG_Mut%  LIHC_Mut%  LUAD_Mut%  LUSC_Mut%  MESO_Mut%  OV_Mut%  PAAD_Mut%  PCPG_Mut%  PRAD_Mut%  READ_Mut%  SARC_Mut%  SKCM_Mut%  STAD_Mut%  TGCT_Mut%  THCA_Mut%  THYM_Mut%  UCEC_Mut%  UCS_Mut%  UVM_Mut% 
WW domain containing E3 ubiquitin protein ligase 1ENSG00000123124WWP1chr8:86342738-86478420:+                                                                  2.07                                                                  
phosphatidylinositol 4-kinase alphaENSG00000241973PI4KAchr22:20707691-20859417:-          0.93                                                                                                                          
inositol 1,4,5-trisphosphate receptor type 1ENSG00000150995ITPR1chr3:4493348-4847840:+          1.45                                                                                                                          
PATJ crumbs cell polarity complex componentENSG00000132849INADLchr1:61742477-62163920:+                                                                      3                                                              
protein tyrosine phosphatase non-receptor type 13ENSG00000163629PTPN13chr4:86594315-86815171:+                                                                  3.01                                                                  
integrin linked kinaseENSG00000166333ILKchr11:6603708-6610874:+                                                                                                                          2          
ras homolog family member BENSG00000143878RHOBchr2:20447074-20449445:+      5.85                                                                                                                              
PX domain containing serine/threonine kinase likeENSG00000168297PXKchr3:58332880-58426126:+                                                                                                      1.18                              
erythrocyte membrane protein band 4.1 like 2ENSG00000079819EPB41L2chr6:130839347-131063322:-                                                                  2.07                                                                  
ATPase phospholipid transporting 8B1ENSG00000081923ATP8B1chr18:57646426-57803101:-                                                                                                                          2.88          
junctophilin 1ENSG00000104369JPH1chr8:74234700-74321328:-          0.52                                                                                                                          
erythrocyte membrane protein band 4.1ENSG00000159023EPB41chr1:28887091-29120046:+                                                                                                      2.61                              
tumor suppressor candidate 3ENSG00000104723TUSC3chr8:15417215-15766649:+                                                                  1.13                                                                  
ATPase secretory pathway Ca2+ transporting 2ENSG00000064270ATP2C2chr16:84368527-84464187:+                                                                                                                      1.65              
tyrosine kinase non receptor 2ENSG00000061938TNK2chr3:195863364-195911945:-                                                                                                                          3.1          
syndecan binding proteinENSG00000137575SDCBPchr8:58552924-58582860:+      1.02                                                                                                                              
regulator of G protein signaling 1ENSG00000090104RGS1chr1:192575727-192580031:+                                                                  1.69                                                                  
glutamic-oxaloacetic transaminase 2ENSG00000125166GOT2chr16:58707131-58734357:-                                  0.77                                                                                                  
LIM domain containing preferred translocation partner in lipomaENSG00000145012LPPchr3:188153284-188890671:+                                                                                                                          1.77          
membrane palmitoylated protein 7ENSG00000150054MPP7chr10:28050993-28334486:-                                                                                                      7.82                              

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