Mutation

 

The putative cancer-causing GESPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the recurrent mutated GESPs in each cancer type


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 HGNC Name  Ensembl Gene ID  HGNC Symbol  Genomic Location  ACC_Mut%  BLCA_Mut%  BRCA_Mut%  CESC_Mut%  CHOL_Mut%  COAD_Mut%  DLBC_Mut%  ESCA_Mut%  GBM_Mut%  HNSC_Mut%  KICH_Mut%  KIRC_Mut%  KIRP_Mut%  LAML_Mut%  LGG_Mut%  LIHC_Mut%  LUAD_Mut%  LUSC_Mut%  MESO_Mut%  OV_Mut%  PAAD_Mut%  PCPG_Mut%  PRAD_Mut%  READ_Mut%  SARC_Mut%  SKCM_Mut%  STAD_Mut%  TGCT_Mut%  THCA_Mut%  THYM_Mut%  UCEC_Mut%  UCS_Mut%  UVM_Mut% 
adhesion G protein-coupled receptor L3ENSG00000150471ADGRL3chr4:61201258-62078335:+                                                                      10.52                                                              
transferrin receptorENSG00000072274TFRCchr3:196027183-196082189:-                                                                                                                          1.33          
protein tyrosine phosphatase receptor type DENSG00000153707PTPRDchr9:8314246-10612723:-                                                                                                      13.74                              
calcium sensing receptorENSG00000036828CASRchr3:122183683-122286503:+                                                                                                      10.66                              
protein tyrosine phosphatase receptor type UENSG00000060656PTPRUchr1:29236516-29326813:+                                                                  2.64                                                                  
toll like receptor 5ENSG00000187554TLR5chr1:223109406-223143282:-                                                                                                          1.36                          
semaphorin 6AENSG00000092421SEMA6Achr5:116443616-116574934:-                                                                                                                          2          
immunoglobulin superfamily member 3ENSG00000143061IGSF3chr1:116574399-116667755:-                                                                                                                          1.77          
signal regulatory protein gammaENSG00000089012SIRPGchr20:1629152-1657779:-                                                                  3.01                                                                  
CD93 moleculeENSG00000125810CD93chr20:23079349-23086340:-                                                                                                                          4.43          
transmembrane 9 superfamily member 1ENSG00000100926TM9SF1chr14:24189143-24195687:-          0.52                                                                                                                          
ATP binding cassette subfamily C member 3ENSG00000108846ABCC3chr17:50634777-50692252:+                                                                  1.51                                                                  
thioredoxin related transmembrane protein 3ENSG00000166479TMX3chr18:68673688-68715298:-                                                                  1.13                                                                  
FAT atypical cadherin 4ENSG00000196159FAT4chr4:125316399-125492932:+                      15.16                                                                                                              
calsyntenin 1ENSG00000171603CLSTN1chr1:9729026-9824526:-                                                                  0.75                                                                  
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3ENSG00000110719TCIRG1chr11:68039016-68050895:+                                                                                                      0.95                              
solute carrier family 11 member 1ENSG00000018280SLC11A1chr2:218382029-218396894:+                                                                  1.32                                                                  
LIM domain and actin binding 1ENSG00000050405LIMA1chr12:50175788-50283546:-                                                                  1.32                                                                  
serine peptidase inhibitor, Kunitz type 1ENSG00000166145SPINT1chr15:40844018-40858207:+                                                                                                      1.66                              
repulsive guidance molecule BMP co-receptor bENSG00000174136RGMBchr5:98768650-98798643:+                      2.26                                                                                                              

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