Mutation

 

The putative cancer-causing GESPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the recurrent mutated GESPs in each cancer type


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 HGNC Name  Ensembl Gene ID  HGNC Symbol  Genomic Location  ACC_Mut%  BLCA_Mut%  BRCA_Mut%  CESC_Mut%  CHOL_Mut%  COAD_Mut%  DLBC_Mut%  ESCA_Mut%  GBM_Mut%  HNSC_Mut%  KICH_Mut%  KIRC_Mut%  KIRP_Mut%  LAML_Mut%  LGG_Mut%  LIHC_Mut%  LUAD_Mut%  LUSC_Mut%  MESO_Mut%  OV_Mut%  PAAD_Mut%  PCPG_Mut%  PRAD_Mut%  READ_Mut%  SARC_Mut%  SKCM_Mut%  STAD_Mut%  TGCT_Mut%  THCA_Mut%  THYM_Mut%  UCEC_Mut%  UCS_Mut%  UVM_Mut% 
neuropilin 2ENSG00000118257NRP2chr2:205681990-205798133:+                                                                  3.01                                                                  
solute carrier family 4 member 7ENSG00000033867SLC4A7chr3:27372721-27484420:-                                                                      1.5                                                              
alkaline phosphatase, placentalENSG00000163283ALPPchr2:232378534-232382889:+                                                                      1.5                                                              
kinase insert domain receptorENSG00000128052KDRchr4:55078477-55125589:-                                                                  6.78                                                                  
leptin receptorENSG00000116678LEPRchr1:65420652-65641559:+                                                                      5.79                                                              
desmocollin 2ENSG00000134755DSC2chr18:31058840-31102415:-                                                                                                      9.95                              
integrin subunit beta 6ENSG00000115221ITGB6chr2:160099666-160271888:-      1.53                                                                                                                              
plexin D1ENSG00000004399PLXND1chr3:129555175-129606818:-                                                              1.11                                                                      
major histocompatibility complex, class I, AENSG00000206503HLA-Achr6:29941260-29945884:+                                      3.59                                                                                              
LDL receptor related protein 12ENSG00000147650LRP12chr8:104489231-104589024:-                                                                                                                          2.66          
plexin B2ENSG00000196576PLXNB2chr22:50274979-50307627:-                                                                                                                          5.99          
interleukin 4 receptorENSG00000077238IL4Rchr16:27313668-27364778:+                                                                                                      2.61                              
plasmalemma vesicle associated proteinENSG00000130300PLVAPchr19:17351448-17377350:-                                                                  1.13                                                                  
protein tyrosine phosphatase receptor type FENSG00000142949PTPRFchr1:43525187-43623666:+                                                                      1.93                                                              
integrin subunit alpha XENSG00000140678ITGAXchr16:31355134-31382997:+                                                                      3.86                                                              
glutamate metabotropic receptor 1ENSG00000152822GRM1chr6:146027646-146437598:+                                                                  6.03                                                                  
leucine rich repeat containing G protein-coupled receptor 5ENSG00000139292LGR5chr12:71439770-71586310:+                                                                  4.33                                                                  
TNF receptor superfamily member 1AENSG00000067182TNFRSF1Achr12:6328757-6342114:-                                                                                                                          1.77          
activin A receptor type 1ENSG00000115170ACVR1chr2:157736444-157875862:-                                                                                                                          4.43          
transmembrane 9 superfamily member 3ENSG00000077147TM9SF3chr10:96518109-96587452:-      1.27                                                                                                                              

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