Mutation

 

The putative cancer-causing GESPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the recurrent mutated GESPs in each cancer type


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 HGNC Name  Ensembl Gene ID  HGNC Symbol  Genomic Location  ACC_Mut%  BLCA_Mut%  BRCA_Mut%  CESC_Mut%  CHOL_Mut%  COAD_Mut%  DLBC_Mut%  ESCA_Mut%  GBM_Mut%  HNSC_Mut%  KICH_Mut%  KIRC_Mut%  KIRP_Mut%  LAML_Mut%  LGG_Mut%  LIHC_Mut%  LUAD_Mut%  LUSC_Mut%  MESO_Mut%  OV_Mut%  PAAD_Mut%  PCPG_Mut%  PRAD_Mut%  READ_Mut%  SARC_Mut%  SKCM_Mut%  STAD_Mut%  TGCT_Mut%  THCA_Mut%  THYM_Mut%  UCEC_Mut%  UCS_Mut%  UVM_Mut% 
ret proto-oncogeneENSG00000165731RETchr10:43077027-43130351:+                                                                                      3.37                                              
fms related receptor tyrosine kinase 4ENSG00000037280FLT4chr5:180601506-180649624:-                                                                  2.82                                                                  
anoctamin 6ENSG00000177119ANO6chr12:45215987-45440404:+                                                                      1.93                                                              
integrin subunit beta 4ENSG00000132470ITGB4chr17:75721328-75757818:+          1.03                                                                                                                          
MET proto-oncogene, receptor tyrosine kinaseENSG00000105976METchr7:116672390-116798386:+                                                  7.83                                                                                  
protein tyrosine phosphatase receptor type MENSG00000173482PTPRMchr18:7566782-8406861:+      3.31                                                                                                                              
leukocyte associated immunoglobulin like receptor 1ENSG00000167613LAIR1chr19:54351384-54370558:-                                                                      1.93                                                              
integrin subunit alpha 4ENSG00000115232ITGA4chr2:181457202-181536187:+                                                                                                      8.77                              
interleukin 6 signal transducerENSG00000134352IL6STchr5:55935095-55994993:-                                                              2.78                                                                      
ATP binding cassette subfamily C member 1ENSG00000103222ABCC1chr16:15949577-16143074:+      2.04                                                                                                                              
integrin subunit beta 3ENSG00000259207ITGB3chr17:47253846-47311816:+      1.78                                                                                                                              
toll like receptor 4ENSG00000136869TLR4chr9:117704332-117716871:+                                                                  10.17                                                                  
neurotrophic receptor tyrosine kinase 1ENSG00000198400NTRK1chr1:156815640-156881850:+                                                              1.39                                                                      
fibroblast growth factor receptor 1ENSG00000077782FGFR1chr8:38411138-38468834:-                                                                  0.75                                                                  
CD79b moleculeENSG00000007312CD79Bchr17:63928740-63932354:-                          13.51                                                                                                          
bone morphogenetic protein receptor type 2ENSG00000204217BMPR2chr2:202376936-202567751:+                                                                                                          2.44                          
CXADR Ig-like cell adhesion moleculeENSG00000154639CXADRchr21:17512382-17593579:+                                                                                                      1.18                              
membrane metalloendopeptidaseENSG00000196549MMEchr3:155024124-155183729:+                                                                                                          1.63                          
colony stimulating factor 2 receptor subunit alphaENSG00000198223CSF2RAchrX:1268800-1310381:+                                                                                                      5.21                              
fms related receptor tyrosine kinase 1ENSG00000102755FLT1chr13:28300344-28495128:-                                                                                                      6.87                              

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