Mutation

 

The putative cancer-causing GESPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the recurrent mutated GESPs in each cancer type


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 HGNC Name  Ensembl Gene ID  HGNC Symbol  Genomic Location  ACC_Mut%  BLCA_Mut%  BRCA_Mut%  CESC_Mut%  CHOL_Mut%  COAD_Mut%  DLBC_Mut%  ESCA_Mut%  GBM_Mut%  HNSC_Mut%  KICH_Mut%  KIRC_Mut%  KIRP_Mut%  LAML_Mut%  LGG_Mut%  LIHC_Mut%  LUAD_Mut%  LUSC_Mut%  MESO_Mut%  OV_Mut%  PAAD_Mut%  PCPG_Mut%  PRAD_Mut%  READ_Mut%  SARC_Mut%  SKCM_Mut%  STAD_Mut%  TGCT_Mut%  THCA_Mut%  THYM_Mut%  UCEC_Mut%  UCS_Mut%  UVM_Mut% 
KIT proto-oncogene, receptor tyrosine kinaseENSG00000157404KITchr4:54657918-54740715:+                                                                                                      3.79        14.58                      
EPH receptor A2ENSG00000142627EPHA2chr1:16124337-16156087:-      4.33                                4.58                                                                                              
adhesion G protein-coupled receptor L2ENSG00000117114ADGRL2chr1:81306160-81992436:+      4.33                        5.52                                                                                                      
selectin LENSG00000188404SELLchr1:169690667-169711698:-                                                                  1.32                                    2.13                              
FAT atypical cadherin 1ENSG00000083857FAT1chr4:186587783-186726722:-                                      22.51                                13.73                                                              
fibronectin leucine rich transmembrane protein 3ENSG00000125848FLRT3chr20:14322988-14337616:-          0.62                                                        2.07                                                                  
notch receptor 1ENSG00000148400NOTCH1chr9:136494444-136545862:-                                      17.33                    7.06                                                                          
EPH receptor A5ENSG00000145242EPHA5chr4:65319563-65670495:-                                                                  10.55    8.8                                                              
fms related receptor tyrosine kinase 3ENSG00000122025FLT3chr13:28003274-28100592:-                                                      5.15                                                6.4                              
ankyrin 3ENSG00000151150ANK3chr10:60026298-60733490:-                                                                                                      28.2                    8.65          
heat shock protein family A (Hsp70) member 8ENSG00000109971HSPA8chr11:123057489-123063230:-      2.54                                                            1.69                                                                  
microtubule affinity regulating kinase 2ENSG00000072518MARK2chr11:63838928-63911019:+      2.54                                                                1.72                                                              
GNAS complex locusENSG00000087460GNASchr20:58839718-58911192:+  3.33                                                                                4.6                                                  
utrophinENSG00000152818UTRNchr6:144285701-144853034:+                                                                      7.94                                    6.78                          
heat shock protein 90 alpha family class A member 1ENSG00000080824HSP90AA1chr14:102080738-102139699:-                                  0.52            1.63                                                                                      
talin 1ENSG00000137076TLN1chr9:35696948-35732395:-                                  1.03                                                                                        3.33          
tetratricopeptide repeat domain 7BENSG00000165914TTC7Bchr14:90524564-90816479:-                                                                  1.32                                    2.37                              
shroom family member 2ENSG00000146950SHROOM2chrX:9786456-9949443:+                                                                      2.36                                                    5.76          
integrin subunit beta 2ENSG00000160255ITGB2chr21:44885953-44931989:-                                  2.32                                                                                                  
integrin subunit beta 1ENSG00000150093ITGB1chr10:32900319-33005792:-                                      2.19                                                                                              

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