GESPs
During the last two decades, both experimental and computational approaches have been applied to identify and predict the proteins located on cell surface membranes, although each strategy has its own limitations leading to incomplete coverage and false positives. To overcome this problem and comprehensively define the human surfaceome in the genome, we integrated GESP candidates from nine independent resources, in which the cell surface proteins were identified or predicted by distinct strategies.
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HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Core GESP Score | Final GESP Score |
dipeptidase 1 | ENSG00000015413 | DPEP1 | chr16:89613308-89638456:+ | 13 | 14.5 |
thromboxane A2 receptor | ENSG00000006638 | TBXA2R | chr19:3594506-3606840:- | 12 | 18 |
adrenoceptor beta 2 | ENSG00000169252 | ADRB2 | chr5:148825245-148828687:+ | 13 | 18 |
sphingosine-1-phosphate receptor 1 | ENSG00000170989 | S1PR1 | chr1:101236888-101241518:+ | 12 | 18 |
adenosine A1 receptor | ENSG00000163485 | ADORA1 | chr1:203090654-203167405:+ | 13 | 17 |
angiotensin II receptor type 1 | ENSG00000144891 | AGTR1 | chr3:148697784-148743008:+ | 13 | 17 |
integrin subunit beta 3 | ENSG00000259207 | ITGB3 | chr17:47253846-47311816:+ | 13 | 21.5 |
insulin receptor | ENSG00000171105 | INSR | chr19:7112255-7294034:- | 13 | 20.5 |
polycystin 2, transient receptor potential cation channel | ENSG00000118762 | PKD2 | chr4:88007668-88077777:+ | 12 | 18.5 |
adhesion G protein-coupled receptor G6 | ENSG00000112414 | ADGRG6 | chr6:142301854-142446266:+ | 13 | 15.5 |
toll like receptor 4 | ENSG00000136869 | TLR4 | chr9:117704332-117716871:+ | 13 | 16.5 |
EPH receptor A2 | ENSG00000142627 | EPHA2 | chr1:16124337-16156087:- | 13 | 20.5 |
neurotrophic receptor tyrosine kinase 1 | ENSG00000198400 | NTRK1 | chr1:156815640-156881850:+ | 13 | 16.5 |
protein tyrosine phosphatase receptor type C | ENSG00000081237 | PTPRC | chr1:198638671-198757283:+ | 12 | 18 |
MAS related GPR family member F | ENSG00000172935 | MRGPRF | chr11:69004395-69013409:- | 12 | 15 |
G protein-coupled receptor class C group 5 member A | ENSG00000013588 | GPRC5A | chr12:12890782-12917937:+ | 13 | 18 |
thyroid stimulating hormone receptor | ENSG00000165409 | TSHR | chr14:80954989-81146302:+ | 13 | 15 |
platelet and endothelial cell adhesion molecule 1 | ENSG00000261371 | PECAM1 | chr17:64319415-64413776:- | 12 | 18.5 |
adhesion G protein-coupled receptor E5 | ENSG00000123146 | ADGRE5 | chr19:14380501-14408725:+ | 13 | 22 |
atypical chemokine receptor 3 | ENSG00000144476 | ACKR3 | chr2:236567787-236582358:+ | 13 | 17 |
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