GESPs
During the last two decades, both experimental and computational approaches have been applied to identify and predict the proteins located on cell surface membranes, although each strategy has its own limitations leading to incomplete coverage and false positives. To overcome this problem and comprehensively define the human surfaceome in the genome, we integrated GESP candidates from nine independent resources, in which the cell surface proteins were identified or predicted by distinct strategies.
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HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Core GESP Score | Final GESP Score |
extracellular leucine rich repeat and fibronectin type III domain containing 1 | ENSG00000225968 | ELFN1 | chr7:1688119-1747954:+ | 9 | 13 |
diacylglycerol lipase beta | ENSG00000164535 | DAGLB | chr7:6409126-6484190:- | 9 | 15.5 |
glycoprotein nmb | ENSG00000136235 | GPNMB | chr7:23235967-23275108:+ | 10 | 13.5 |
NPC1 like intracellular cholesterol transporter 1 | ENSG00000015520 | NPC1L1 | chr7:44512535-44541315:- | 9 | 10.5 |
ATP binding cassette subfamily B member 4 | ENSG00000005471 | ABCB4 | chr7:87401697-87480435:- | 9 | 10.5 |
transferrin receptor 2 | ENSG00000106327 | TFR2 | chr7:100620416-100642779:- | 9 | 11.5 |
acetylcholinesterase (Cartwright blood group) | ENSG00000087085 | ACHE | chr7:100889994-100896974:- | 9 | 12.5 |
mucin 17, cell surface associated | ENSG00000169876 | MUC17 | chr7:101020072-101058745:+ | 9 | 10.5 |
transient receptor potential cation channel subfamily V member 5 | ENSG00000127412 | TRPV5 | chr7:142908101-142933808:- | 10 | 11.5 |
sarcoglycan zeta | ENSG00000185053 | SGCZ | chr8:14089864-15238339:- | 10 | 11.5 |
scavenger receptor class A member 5 | ENSG00000168079 | SCARA5 | chr8:27869882-27992727:- | 9 | 10.5 |
ADAM metallopeptidase domain 9 | ENSG00000168615 | ADAM9 | chr8:38996869-39105144:+ | 9 | 16.5 |
syndecan 2 | ENSG00000169439 | SDC2 | chr8:96493351-96611780:+ | 9 | 13.5 |
programmed cell death 1 ligand 2 | ENSG00000197646 | PDCD1LG2 | chr9:5510570-5571254:+ | 10 | 14.5 |
crumbs cell polarity complex component 2 | ENSG00000148204 | CRB2 | chr9:123356170-123380324:+ | 10 | 13.5 |
cytokine receptor like factor 2 | ENSG00000205755 | CRLF2 | chrX:1187549-1212750:- | 10 | 12.5 |
gap junction protein beta 1 | ENSG00000169562 | GJB1 | chrX:71215194-71225516:+ | 10 | 11.5 |
protocadherin 19 | ENSG00000165194 | PCDH19 | chrX:100291644-100410273:- | 10 | 11.5 |
glutamate ionotropic receptor AMPA type subunit 3 | ENSG00000125675 | GRIA3 | chrX:123184153-123490915:+ | 10 | 11.5 |
CD40 ligand | ENSG00000102245 | CD40LG | chrX:136648193-136660390:+ | 9 | 10.5 |
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