GESPs
During the last two decades, both experimental and computational approaches have been applied to identify and predict the proteins located on cell surface membranes, although each strategy has its own limitations leading to incomplete coverage and false positives. To overcome this problem and comprehensively define the human surfaceome in the genome, we integrated GESP candidates from nine independent resources, in which the cell surface proteins were identified or predicted by distinct strategies.
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HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Core GESP Score | Final GESP Score |
CEA cell adhesion molecule 5 | ENSG00000105388 | CEACAM5 | chr19:41576273-41729798:+ | 11 | 13 |
reticulon 4 receptor | ENSG00000040608 | RTN4R | chr22:20241415-20283246:- | 11 | 12.5 |
gamma-glutamyltransferase 5 | ENSG00000099998 | GGT5 | chr22:24219654-24245142:- | 12 | 17 |
platelet activating factor receptor | ENSG00000169403 | PTAFR | chr1:28147166-28193936:- | 10 | 16 |
apelin receptor | ENSG00000134817 | APLNR | chr11:57233577-57237314:- | 11 | 16 |
C-X-C motif chemokine receptor 1 | ENSG00000163464 | CXCR1 | chr2:218162845-218166995:- | 11 | 16 |
neuropeptide Y receptor Y1 | ENSG00000164128 | NPY1R | chr4:163323961-163344832:- | 10 | 15 |
opioid receptor kappa 1 | ENSG00000082556 | OPRK1 | chr8:53225716-53251697:- | 11 | 16 |
5-hydroxytryptamine receptor 2B | ENSG00000135914 | HTR2B | chr2:231108230-231125118:- | 11 | 15 |
coagulation factor II thrombin receptor | ENSG00000181104 | F2R | chr5:76716043-76735781:+ | 11 | 17 |
angiotensin II receptor type 2 | ENSG00000180772 | AGTR2 | chrX:116170722-116174972:+ | 11 | 15 |
5-hydroxytryptamine receptor 7 | ENSG00000148680 | HTR7 | chr10:90740823-90857698:- | 11 | 13 |
purinergic receptor P2Y11 | ENSG00000244165 | P2RY11 | chr19:10111538-10115372:+ | 10 | 14 |
ATP binding cassette subfamily G member 2 (Junior blood group) | ENSG00000118777 | ABCG2 | chr4:88090264-88231322:- | 10 | 15.5 |
adhesion G protein-coupled receptor L4 | ENSG00000162618 | ADGRL4 | chr1:78889764-79006718:- | 11 | 14 |
semaphorin 4G | ENSG00000095539 | SEMA4G | chr10:100969518-100985871:+ | 11 | 13 |
fibroblast growth factor receptor 2 | ENSG00000066468 | FGFR2 | chr10:121478334-121598458:- | 11 | 14 |
C-X-C motif chemokine receptor 5 | ENSG00000160683 | CXCR5 | chr11:118883766-118897799:+ | 11 | 14 |
lysophosphatidic acid receptor 5 | ENSG00000184574 | LPAR5 | chr12:6618835-6636447:- | 10 | 13 |
chemerin chemokine-like receptor 1 | ENSG00000174600 | CMKLR1 | chr12:108288044-108339341:- | 10 | 12 |
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