GESPs

 

During the last two decades, both experimental and computational approaches have been applied to identify and predict the proteins located on cell surface membranes, although each strategy has its own limitations leading to incomplete coverage and false positives. To overcome this problem and comprehensively define the human surfaceome in the genome, we integrated GESP candidates from nine independent resources, in which the cell surface proteins were identified or predicted by distinct strategies.

List of the GESPs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationCore GESP ScoreFinal GESP Score
dystrophinENSG00000198947DMDchrX:31097677-33339441:-46
heparan sulfate 2-O-sulfotransferase 1ENSG00000153936HS2ST1chr1:86914648-87109998:+48.5
protein tyrosine phosphatase non-receptor type 22ENSG00000134242PTPN22chr1:113813811-113871759:-44.5
phosphoinositide-3-kinase adaptor protein 1ENSG00000155629PIK3AP1chr10:96593312-96720514:-45
p21 (RAC1) activated kinase 1ENSG00000149269PAK1chr11:77321707-77474635:-57.5
nitric oxide synthase 1ENSG00000089250NOS1chr12:117208142-117452170:-55.5
lymphocyte cytosolic protein 1ENSG00000136167LCP1chr13:46125920-46211871:-49
stereocilinENSG00000242866STRCchr15:43599398-43618800:-45
nucleotide binding oligomerization domain containing 2ENSG00000167207NOD2chr16:50693603-50733077:+44
protein kinase N1ENSG00000123143PKN1chr19:14433053-14471867:+46.5
AP2 associated kinase 1ENSG00000115977AAK1chr2:69457997-69674349:-46.5
LY6/PLAUR domain containing 6ENSG00000187123LYPD6chr2:149329985-149474148:+44
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4ENSG00000113532ST8SIA4chr5:100806935-100903266:-44.5
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaENSG00000105851PIK3CGchr7:106865278-106907145:+56
netrin G2ENSG00000196358NTNG2chr9:132161676-132244534:+44
NHS actin remodeling regulatorENSG00000188158NHSchrX:17375420-17735994:+45
G protein subunit beta 1ENSG00000078369GNB1chr1:1785285-1891117:-412
chloride intracellular channel 4ENSG00000169504CLIC4chr1:24745357-24844324:+49
FGR proto-oncogene, Src family tyrosine kinaseENSG00000000938FGRchr1:27612064-27635277:-55
tenascin RENSG00000116147TNRchr1:175315194-175743770:-44.5

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