GESPs
During the last two decades, both experimental and computational approaches have been applied to identify and predict the proteins located on cell surface membranes, although each strategy has its own limitations leading to incomplete coverage and false positives. To overcome this problem and comprehensively define the human surfaceome in the genome, we integrated GESP candidates from nine independent resources, in which the cell surface proteins were identified or predicted by distinct strategies.
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HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Core GESP Score | Final GESP Score |
dystrophin | ENSG00000198947 | DMD | chrX:31097677-33339441:- | 4 | 6 |
heparan sulfate 2-O-sulfotransferase 1 | ENSG00000153936 | HS2ST1 | chr1:86914648-87109998:+ | 4 | 8.5 |
protein tyrosine phosphatase non-receptor type 22 | ENSG00000134242 | PTPN22 | chr1:113813811-113871759:- | 4 | 4.5 |
phosphoinositide-3-kinase adaptor protein 1 | ENSG00000155629 | PIK3AP1 | chr10:96593312-96720514:- | 4 | 5 |
p21 (RAC1) activated kinase 1 | ENSG00000149269 | PAK1 | chr11:77321707-77474635:- | 5 | 7.5 |
nitric oxide synthase 1 | ENSG00000089250 | NOS1 | chr12:117208142-117452170:- | 5 | 5.5 |
lymphocyte cytosolic protein 1 | ENSG00000136167 | LCP1 | chr13:46125920-46211871:- | 4 | 9 |
stereocilin | ENSG00000242866 | STRC | chr15:43599398-43618800:- | 4 | 5 |
nucleotide binding oligomerization domain containing 2 | ENSG00000167207 | NOD2 | chr16:50693603-50733077:+ | 4 | 4 |
protein kinase N1 | ENSG00000123143 | PKN1 | chr19:14433053-14471867:+ | 4 | 6.5 |
AP2 associated kinase 1 | ENSG00000115977 | AAK1 | chr2:69457997-69674349:- | 4 | 6.5 |
LY6/PLAUR domain containing 6 | ENSG00000187123 | LYPD6 | chr2:149329985-149474148:+ | 4 | 4 |
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | ENSG00000113532 | ST8SIA4 | chr5:100806935-100903266:- | 4 | 4.5 |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | ENSG00000105851 | PIK3CG | chr7:106865278-106907145:+ | 5 | 6 |
netrin G2 | ENSG00000196358 | NTNG2 | chr9:132161676-132244534:+ | 4 | 4 |
NHS actin remodeling regulator | ENSG00000188158 | NHS | chrX:17375420-17735994:+ | 4 | 5 |
G protein subunit beta 1 | ENSG00000078369 | GNB1 | chr1:1785285-1891117:- | 4 | 12 |
chloride intracellular channel 4 | ENSG00000169504 | CLIC4 | chr1:24745357-24844324:+ | 4 | 9 |
FGR proto-oncogene, Src family tyrosine kinase | ENSG00000000938 | FGR | chr1:27612064-27635277:- | 5 | 5 |
tenascin R | ENSG00000116147 | TNR | chr1:175315194-175743770:- | 4 | 4.5 |
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