GESPs
During the last two decades, both experimental and computational approaches have been applied to identify and predict the proteins located on cell surface membranes, although each strategy has its own limitations leading to incomplete coverage and false positives. To overcome this problem and comprehensively define the human surfaceome in the genome, we integrated GESP candidates from nine independent resources, in which the cell surface proteins were identified or predicted by distinct strategies.
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HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Core GESP Score | Final GESP Score |
tight junction protein 1 | ENSG00000104067 | TJP1 | chr15:29699367-29968865:- | 6 | 10 |
SLC9A3 regulator 2 | ENSG00000065054 | SLC9A3R2 | chr16:2025356-2039026:+ | 5 | 8 |
myosin IC | ENSG00000197879 | MYO1C | chr17:1464098-1492812:- | 6 | 12 |
caveolae associated protein 1 | ENSG00000177469 | PTRF | chr17:42402452-42423517:- | 5 | 9 |
microtubule associated protein tau | ENSG00000186868 | MAPT | chr17:45894382-46028334:+ | 6 | 6 |
SLC9A3 regulator 1 | ENSG00000109062 | SLC9A3R1 | chr17:74748652-74769353:+ | 5 | 8 |
paralemmin | ENSG00000099864 | PALM | chr19:708939-748329:+ | 5 | 6 |
vasodilator stimulated phosphoprotein | ENSG00000125753 | VASP | chr19:45506579-45526983:+ | 5 | 8 |
EH domain containing 2 | ENSG00000024422 | EHD2 | chr19:47713343-47743134:+ | 5 | 9 |
cytohesin 2 | ENSG00000105443 | CYTH2 | chr19:48469032-48482314:+ | 5 | 6 |
EH domain containing 3 | ENSG00000013016 | EHD3 | chr2:31234337-31269447:+ | 5 | 6 |
adducin 2 | ENSG00000075340 | ADD2 | chr2:70607618-70768225:- | 6 | 7 |
plakophilin 4 | ENSG00000144283 | PKP4 | chr2:158456964-158682879:+ | 6 | 8 |
ADP ribosylation factor like GTPase 4C | ENSG00000188042 | ARL4C | chr2:234493041-234497053:- | 6 | 6 |
protein phosphatase 1 regulatory subunit 16B | ENSG00000101445 | PPP1R16B | chr20:38805705-38923024:+ | 5 | 5 |
ribosomal protein SA | ENSG00000168028 | RPSA | chr3:39406689-39412542:+ | 5 | 11 |
catenin beta 1 | ENSG00000168036 | CTNNB1 | chr3:41194837-41260096:+ | 6 | 10 |
growth associated protein 43 | ENSG00000172020 | GAP43 | chr3:115623324-115721490:+ | 6 | 7 |
discs large MAGUK scaffold protein 1 | ENSG00000075711 | DLG1 | chr3:197042560-197299300:- | 6 | 10 |
tec protein tyrosine kinase | ENSG00000135605 | TEC | chr4:48135783-48269864:- | 5 | 5 |
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