GESPs
During the last two decades, both experimental and computational approaches have been applied to identify and predict the proteins located on cell surface membranes, although each strategy has its own limitations leading to incomplete coverage and false positives. To overcome this problem and comprehensively define the human surfaceome in the genome, we integrated GESP candidates from nine independent resources, in which the cell surface proteins were identified or predicted by distinct strategies.
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HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Core GESP Score | Final GESP Score |
TNF receptor superfamily member 25 | ENSG00000215788 | TNFRSF25 | chr1:6461151-6466195:- | 11 | 14.5 |
nicastrin | ENSG00000162736 | NCSTN | chr1:160343272-160358952:+ | 12 | 21.5 |
semaphorin 6D | ENSG00000137872 | SEMA6D | chr15:47184101-47774223:+ | 12 | 15 |
kinase insert domain receptor | ENSG00000128052 | KDR | chr4:55078477-55125589:- | 12 | 14.5 |
lysophosphatidic acid receptor 4 | ENSG00000147145 | LPAR4 | chrX:78747709-78757094:+ | 12 | 14 |
transient receptor potential cation channel subfamily C member 6 | ENSG00000137672 | TRPC6 | chr11:101451564-101872562:- | 12 | 16.5 |
cell adhesion associated, oncogene regulated | ENSG00000064309 | CDON | chr11:125955796-126063335:- | 11 | 14 |
fibronectin leucine rich transmembrane protein 2 | ENSG00000185070 | FLRT2 | chr14:85530144-85654426:+ | 11 | 14 |
adhesion G protein-coupled receptor G1 | ENSG00000205336 | ADGRG1 | chr16:57610652-57665580:+ | 12 | 18 |
crumbs cell polarity complex component 3 | ENSG00000130545 | CRB3 | chr19:6463777-6467221:+ | 11 | 12.5 |
low density lipoprotein receptor | ENSG00000130164 | LDLR | chr19:11089362-11133816:+ | 11 | 19 |
fibronectin leucine rich transmembrane protein 3 | ENSG00000125848 | FLRT3 | chr20:14322988-14337616:- | 11 | 15.5 |
interferon alpha and beta receptor subunit 1 | ENSG00000142166 | IFNAR1 | chr21:33324477-33359862:+ | 12 | 16.5 |
colony stimulating factor 2 receptor subunit beta | ENSG00000100368 | CSF2RB | chr22:36913628-36940449:+ | 11 | 15.5 |
glutamate ionotropic receptor AMPA type subunit 2 | ENSG00000120251 | GRIA2 | chr4:157204182-157366075:+ | 12 | 15 |
colony stimulating factor 1 receptor | ENSG00000182578 | CSF1R | chr5:150053291-150113372:- | 12 | 14.5 |
adhesion G protein-coupled receptor F5 | ENSG00000069122 | ADGRF5 | chr6:46852512-46954943:- | 11 | 13 |
ATP binding cassette subfamily B member 1 | ENSG00000085563 | ABCB1 | chr7:87503633-87713323:- | 11 | 15.5 |
STEAP4 metalloreductase | ENSG00000127954 | STEAP4 | chr7:88270892-88306891:- | 12 | 16.5 |
potassium voltage-gated channel subfamily H member 2 | ENSG00000055118 | KCNH2 | chr7:150944961-150978315:- | 12 | 16.5 |
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