GESPs
During the last two decades, both experimental and computational approaches have been applied to identify and predict the proteins located on cell surface membranes, although each strategy has its own limitations leading to incomplete coverage and false positives. To overcome this problem and comprehensively define the human surfaceome in the genome, we integrated GESP candidates from nine independent resources, in which the cell surface proteins were identified or predicted by distinct strategies.
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HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Core GESP Score | Final GESP Score |
sortilin related VPS10 domain containing receptor 1 | ENSG00000108018 | SORCS1 | chr10:106573663-107164534:- | 12 | 13.5 |
zinc finger DHHC-type palmitoyltransferase 5 | ENSG00000156599 | ZDHHC5 | chr11:57667747-57701187:+ | 12 | 15.5 |
membrane spanning 4-domains A1 | ENSG00000156738 | MS4A1 | chr11:60455752-60470760:+ | 12 | 15.5 |
folate receptor alpha | ENSG00000110195 | FOLR1 | chr11:72189558-72196301:+ | 13 | 16.5 |
sortilin related receptor 1 | ENSG00000137642 | SORL1 | chr11:121452203-121633693:+ | 12 | 17.5 |
integrin subunit alpha 7 | ENSG00000135424 | ITGA7 | chr12:55684568-55716043:- | 12 | 17.5 |
LDL receptor related protein 1 | ENSG00000123384 | LRP1 | chr12:57128493-57213351:+ | 12 | 19.5 |
purinergic receptor P2X 7 | ENSG00000089041 | P2RX7 | chr12:121132819-121188032:+ | 13 | 17.5 |
ATPase H+ transporting V0 subunit a2 | ENSG00000185344 | ATP6V0A2 | chr12:123712318-123761755:+ | 13 | 18.5 |
fms related receptor tyrosine kinase 1 | ENSG00000102755 | FLT1 | chr13:28300344-28495128:- | 13 | 15 |
solute carrier family 7 member 5 | ENSG00000103257 | SLC7A5 | chr16:87830023-87869488:- | 12 | 19.5 |
solute carrier family 2 member 4 | ENSG00000181856 | SLC2A4 | chr17:7281667-7288257:+ | 12 | 13.5 |
transient receptor potential cation channel subfamily V member 2 | ENSG00000187688 | TRPV2 | chr17:16415542-16437003:+ | 13 | 18.5 |
solute carrier family 39 member 6 | ENSG00000141424 | SLC39A6 | chr18:36108532-36129385:- | 13 | 19.5 |
intercellular adhesion molecule 1 | ENSG00000090339 | ICAM1 | chr19:10270835-10286615:+ | 13 | 21.5 |
amyloid beta precursor like protein 1 | ENSG00000105290 | APLP1 | chr19:35867899-35879791:+ | 12 | 14.5 |
MER proto-oncogene, tyrosine kinase | ENSG00000153208 | MERTK | chr2:111898479-112029561:+ | 13 | 16.5 |
LDL receptor related protein 2 | ENSG00000081479 | LRP2 | chr2:169127109-169362685:- | 12 | 13.5 |
neuropilin 2 | ENSG00000118257 | NRP2 | chr2:205681990-205798133:+ | 12 | 18.5 |
solute carrier organic anion transporter family member 4A1 | ENSG00000101187 | SLCO4A1 | chr20:62642445-62685785:+ | 12 | 15.5 |
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