V-set domain containing T cell activation inhibitor 1
Location:
1p13.1-p12
Also known as:
FLJ22418, B7-H4, B7X, B7H4, B7S1
Entrez ID:
79679
Ensembl ID:
ENSG00000134258
Summary:
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Overall distribution
Tissue specific distribution
Expression restricted in 4 cancer type(s)
Cancer specific in breast cancer subtype (Basal; ER; LumA; Nor)
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.00
Gscore (Del):
0.14
Recurrently deleted in 2 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
0.00
Overall
Tissue specific
Total fusion occurrence:
2
Fusions detected in 2 cancer type(s)
Overall
Tissue specific
Functional class:
Not specified
JensenLab PubMed score:
178.53 (Percentile rank: 80.40%)
PubTator score:
108.05 (Percentile rank: 78.78%)
Target development/druggability level:
TbioThese targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: 1) target is above the cutoff criteria for Tdark; 2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code.
Tractability (small molecule):
N/A
Tractability (antibody):
Predicted Tractable - Medium to low confidenceTargets with GO cell component terms plasma membrane or secreted with low or unknown confidence; Targets with predicted signal peptide and transmembrane domains; GO cell component - medium confidence; Human Protein Atlas - high confidence
