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SLC34A3  
    


    
      Official symbol:  SLC34A3
      Full name:  solute carrier family 34 member 3
      Location:  9q34.3
      Also known as:  NPTIIc, FLJ38680
      Entrez ID:  142680
      Ensembl ID:  ENSG00000198569
      Summary:  This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.[provided by RefSeq, Apr 2010]

    

    
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  Tissue specific distribution
    
 
  
 
   

    
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  Tissue specific distribution
    
 
Gscore (Amp):  0.00  
Gscore (Del):  0.00  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Mscore:  0.00  
 
   

    
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  Tissue specific
    
 
Total fusion occurrence:  0  
 
 
 

    
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  Tissue specific
    
     
   

    
      Functional class:  Transporter
      JensenLab PubMed score:  49.13  (Percentile rank: 62.08%)
      PubTator score:  33.08  (Percentile rank: 61.07%)
      Target development/druggability level:  TbioThese targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: 1) target is above the cutoff criteria for Tdark; 2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code.
      Tractability (small molecule):  N/A
      Tractability (antibody):  Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted

    







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