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PTPRD  
    


    
      Official symbol:  PTPRD
      Full name:  protein tyrosine phosphatase, receptor type D
      Location:  9p24.1-p23
      Also known as:  PTPD, HPTP
      Entrez ID:  5789
      Ensembl ID:  ENSG00000153707
      Summary:  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]

    

    
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  Overall distribution
    
  Tissue specific distribution
    
 
Gscore (Amp):  0.00  
Gscore (Del):  0.76  (Driver)
 
Recurrently deleted in 3 cancer type(s)
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Mscore:  0.27  (Driver)
 
Recurrently mutated in 1 cancer type(s)
   

    
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  Tissue specific
    
 
Total fusion occurrence:  13  (Driver)
 
Fusions detected in 10 cancer type(s)
 
 

    
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  Tissue specific
    
     
   

    
      Functional class:  Enzyme
      JensenLab PubMed score:  199.34  (Percentile rank: 81.64%)
      PubTator score:  78.43  (Percentile rank: 74.50%)
      Target development/druggability level:  TbioThese targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: 1) target is above the cutoff criteria for Tdark; 2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code.
      Tractability (small molecule):  N/A
      Tractability (antibody):  Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted

    







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