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PRSS21  
    


    
      Official symbol:  PRSS21
      Full name:  serine protease 21
      Location:  16p13.3
      Also known as:  ESP-1, TEST1
      Entrez ID:  10942
      Ensembl ID:  ENSG00000007038
      Summary:  This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

    

    
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  Tissue specific distribution
    
 
  
 
Expression restricted in 2 cancer type(s)
   

    
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  Tissue specific distribution
    
 
Gscore (Amp):  0.00  
Gscore (Del):  0.00  
 
   

    
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  Tissue specific distribution
    
 
Mscore:  0.00  
 
   

    
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Total fusion occurrence:  0  
 
 
 

    
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      Functional class:  Enzyme
      JensenLab PubMed score:  118.44  (Percentile rank: 75.07%)
      PubTator score:  511.87  (Percentile rank: 93.45%)
      Target development/druggability level:  TbioThese targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: 1) target is above the cutoff criteria for Tdark; 2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code.
      Tractability (small molecule):  N/A
      Tractability (antibody):  Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted

    







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