mal, T cell differentiation protein 2 (gene/pseudogene)
Location:
8q24.12
Also known as:
Entrez ID:
114569
Ensembl ID:
ENSG00000147676
Summary:
This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]
Overall distribution
Tissue specific distribution
Expression restricted in 5 cancer type(s)
Cancer specific in breast cancer subtype (Her2; LumB)
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.91 (Driver)
Gscore (Del):
0.00
Recurrently amplified in 1 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
0.00
Overall
Tissue specific
Total fusion occurrence:
0
N/A
Functional class:
Not specified
JensenLab PubMed score:
NA (Percentile rank: NA)
PubTator score:
27.59 (Percentile rank: 58.02%)
Target development/druggability level:
TdarkThese are targets about which virtually nothing is known. They do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy two or more of the following criteria: 1) A PubMed text-mining score from Jensen Lab < 5; 2) <= 3 Gene RIFs; 3) <= 50 Antibodies available according to http://antibodypedia.com.
Tractability (small molecule):
N/A
Tractability (antibody):
Predicted Tractable - Medium to low confidenceTargets with GO cell component terms plasma membrane or secreted with low or unknown confidence; Targets with predicted signal peptide and transmembrane domains; GO cell component - medium confidence; Human Protein Atlas - high confidence
