potassium calcium-activated channel subfamily M alpha 1
Location:
10q22.3
Also known as:
KCa1.1, SLO, mSLO1
Entrez ID:
3778
Ensembl ID:
ENSG00000156113
Summary:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Overall distribution
Tissue specific distribution
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.00
Gscore (Del):
0.00
Overall distribution
Tissue specific distribution
Mscore:
0.00
Overall
Tissue specific
Total fusion occurrence:
12 (Driver)
Fusions detected in 5 cancer type(s)
Overall
Tissue specific
Functional class:
Ion channel
JensenLab PubMed score:
1238.47 (Percentile rank: 96.37%)
PubTator score:
306.08 (Percentile rank: 89.91%)
Target development/druggability level:
TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
Tractability (small molecule):
Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
Tractability (antibody):
Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted
