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KCNA7  
    


    
      Official symbol:  KCNA7
      Full name:  potassium voltage-gated channel subfamily A member 7
      Location:  19q13.33
      Also known as:  HAK6, Kv1.7
      Entrez ID:  3743
      Ensembl ID:  ENSG00000104848
      Summary:  Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]

    

    
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Gscore (Amp):  0.00  
Gscore (Del):  0.00  
 
   

    
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  Tissue specific distribution
    
 
Mscore:  0.00  
 
   

    
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Total fusion occurrence:  0  
 
 
 

    
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      Functional class:  Ion channel
      JensenLab PubMed score:  7.43  (Percentile rank: 32.17%)
      PubTator score:  7.45  (Percentile rank: 34.91%)
      Target development/druggability level:  TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted

    







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