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KCNA10  
    


    
      Official symbol:  KCNA10
      Full name:  potassium voltage-gated channel subfamily A member 10
      Location:  1p13.3
      Also known as:  Kv1.8
      Entrez ID:  3744
      Ensembl ID:  ENSG00000143105
      Summary:  Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]

    

    
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  Tissue specific distribution
    
 
Gscore (Amp):  0.00  
Gscore (Del):  0.00  
 
   

    
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  Tissue specific distribution
    
 
Mscore:  0.00  
 
   

    
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Total fusion occurrence:  0  
 
 
 

    
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  Tissue specific
    
   COMMON ESSENTIAL     
   

    
      Functional class:  Ion channel
      JensenLab PubMed score:  13.32  (Percentile rank: 40.85%)
      PubTator score:  8.74  (Percentile rank: 37.64%)
      Target development/druggability level:  TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted

    







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