heat shock protein 90 alpha family class A member 1
Location:
14q32.31
Also known as:
HSPCA, Hsp90, HSPC1, HSP90N, FLJ31884, Hsp89
Entrez ID:
3320
Ensembl ID:
ENSG00000080824
Summary:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Overall distribution
Tissue specific distribution
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.17
Gscore (Del):
0.31
Recurrently amplified in 1 cancer type(s)
Recurrently deleted in 1 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
0.04
Recurrently mutated in 2 cancer type(s)
Overall
Tissue specific
Total fusion occurrence:
4
Fusions detected in 4 cancer type(s)
Overall
Tissue specific
Functional class:
Not specified
JensenLab PubMed score:
4681.47 (Percentile rank: 99.22%)
PubTator score:
2607.81 (Percentile rank: 98.77%)
Target development/druggability level:
TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
Tractability (small molecule):
Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
Tractability (antibody):
Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted
