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EGFR  
    


    
      Official symbol:  EGFR
      Full name:  epidermal growth factor receptor
      Location:  7p11.2
      Also known as:  ERBB1, ERBB
      Entrez ID:  1956
      Ensembl ID:  ENSG00000146648
      Summary:  The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]

    

    
  Overall distribution
    
  Tissue specific distribution
    
 
  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Gscore (Amp):  3.05  (Driver)
Gscore (Del):  0.00  
 
Recurrently amplified in 7 cancer type(s)
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Mscore:  2.15  (Driver)
 
Recurrently mutated in 4 cancer type(s)
   

    
  Overall
    
  Tissue specific
    
 
Total fusion occurrence:  16  (Driver)
 
Fusions detected in 6 cancer type(s)
 
 

    
  Overall
    
  Tissue specific
    
   STRONGLY SELECTIVE     
   

    
      Functional class:  Kinase (protein kinase)
      JensenLab PubMed score:  10013.12  (Percentile rank: 99.72%)
      PubTator score:  20799.95  (Percentile rank: 99.96%)
      Target development/druggability level:  TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets

    







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