GESPs

 

During the last two decades, both experimental and computational approaches have been applied to identify and predict the proteins located on cell surface membranes, although each strategy has its own limitations leading to incomplete coverage and false positives. To overcome this problem and comprehensively define the human surfaceome in the genome, we integrated GESP candidates from nine independent resources, in which the cell surface proteins were identified or predicted by distinct strategies.

List of the GESPs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationCore GESP ScoreFinal GESP Score
piezo type mechanosensitive ion channel component 2ENSG00000154864PIEZO2chr18:10666483-11148762:-812
thioredoxin related transmembrane protein 3ENSG00000166479TMX3chr18:68673688-68715298:-714.5
calcium voltage-gated channel subunit alpha1 AENSG00000141837CACNA1Achr19:13206442-13623990:-78.5
notch receptor 3ENSG00000074181NOTCH3chr19:15159038-15200981:-711
leucine rich repeat containing 25ENSG00000175489LRRC25chr19:18391144-18397617:-79.5
ATPase H+/K+ transporting subunit alphaENSG00000105675ATP4Achr19:35550043-35563658:-79.5
NPHS1 adhesion molecule, nephrinENSG00000161270NPHS1chr19:35825964-35869287:-78
potassium voltage-gated channel subfamily C member 3ENSG00000131398KCNC3chr19:50311937-50333515:-89.5
sialic acid binding Ig like lectin 5ENSG00000105501SIGLEC5chr19:51611503-51645545:-79.5
V-set and transmembrane domain containing 1ENSG00000189068VSTM1chr19:54040825-54063953:-78.5
solute carrier family 5 member 6ENSG00000138074SLC5A6chr2:27199587-27212958:-713.5
potassium voltage-gated channel modifier subfamily G member 3ENSG00000171126KCNG3chr2:42442017-42494097:-89.5
potassium inwardly rectifying channel subfamily J member 3ENSG00000162989KCNJ3chr2:154698299-154858352:+78.5
solute carrier family 19 member 3ENSG00000135917SLC19A3chr2:227685210-227718012:-810.5
solute carrier family 12 member 5ENSG00000124140SLC12A5chr20:46021690-46060152:+78.5
potassium voltage-gated channel modifier subfamily G member 1ENSG00000026559KCNG1chr20:51003656-51023129:-89.5
claudin 17ENSG00000156282CLDN17chr21:30165564-30166756:-89.5
claudin 5ENSG00000184113CLDN5chr22:19523024-19527545:-89.5
proline rich transmembrane protein 3ENSG00000163704PRRT3chr3:9945542-9952394:-79.5
teratocarcinoma-derived growth factor 1ENSG00000241186TDGF1chr3:46574555-46626543:+78

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