GESPs

 

During the last two decades, both experimental and computational approaches have been applied to identify and predict the proteins located on cell surface membranes, although each strategy has its own limitations leading to incomplete coverage and false positives. To overcome this problem and comprehensively define the human surfaceome in the genome, we integrated GESP candidates from nine independent resources, in which the cell surface proteins were identified or predicted by distinct strategies.

List of the GESPs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationCore GESP ScoreFinal GESP Score
synaptotagmin like 1ENSG00000142765SYTL1chr1:27342020-27353937:+44
regulator of G protein signaling 1ENSG00000090104RGS1chr1:192575727-192580031:+44
regulator of G protein signaling 2ENSG00000116741RGS2chr1:192809039-192812283:+44
calcium voltage-gated channel auxiliary subunit beta 2ENSG00000165995CACNB2chr10:18140677-18541869:+44
RAB11 family interacting protein 2ENSG00000107560RAB11FIP2chr10:118004916-118046603:-45
caveolae associated protein 3ENSG00000170955PRKCDBPchr11:6318946-6320647:-46
lin-7 homolog C, crumbs cell polarity complex componentENSG00000148943LIN7Cchr11:27494576-27506773:-46
RAB35, member RAS oncogene familyENSG00000111737RAB35chr12:120095095-120117502:-49
APC membrane recruitment protein 2ENSG00000165566AMER2chr13:25161684-25172288:-44
pleckstrin 2ENSG00000100558PLEK2chr14:67386983-67412200:-44
SHC adaptor protein 4ENSG00000185634SHC4chr15:48823735-48963444:-44
ubiquitin specific peptidase 8ENSG00000138592USP8chr15:50424380-50514419:+46
FES proto-oncogene, tyrosine kinaseENSG00000182511FESchr15:90883695-90895776:+45
Bardet-Biedl syndrome 2ENSG00000125124BBS2chr16:56466836-56520283:-45
glutamic-oxaloacetic transaminase 2ENSG00000125166GOT2chr16:58707131-58734357:-410
ArfGAP with dual PH domains 2ENSG00000184060ADAP2chr17:30906344-30959322:+45
ADP ribosylation factor like GTPase 4DENSG00000175906ARL4Dchr17:43398959-43401137:+44
G protein subunit gamma transducin 2ENSG00000167083GNGT2chr17:49202791-49210574:-44
protein phosphatase 1 regulatory subunit 9BENSG00000108819PPP1R9Bchr17:50133735-50150630:-46
Rac family small GTPase 3ENSG00000169750RAC3chr17:82031624-82034204:+48

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