Copy Number

 

The putative cancer-associated GESPs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).

 

Summary of the G-score of the putative cancer-causing GESPs driven by SCNAs in each cancer type


 Show   entries each page
 Jump to page  

 
 Showing page 32  first page | previous page | next page | last page 
 
ACCBLCABRCACESCCHOLCOADDLBCESCAGBMHNSCKICHKIRCKIRPLAMLLGGLIHCLUADLUSCMESOOVPAADPCPGPRADREADSARCSKCMSTADTGCTTHCATHYMUCECUCSUVM
 HGNC Name  Ensembl Gene ID  HGNC Symbol  Genomic Location  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del 
sushi domain containing 6ENSG00000100647SUSD6chr14:69611596-69715142:+                      0.1                                                                                                0.11                                        0.26                                        0.14                                                                  
ras homolog family member CENSG00000155366RHOCchr1:112701106-112707434:-                                                                              0.14                                                        0.14                0.33                                                                                                                  
inositol 1,4,5-trisphosphate receptor interacting proteinENSG00000148841ITPRIPchr10:104309698-104338404:-                                              0.1                                                                                                        0.2        0.31                                                                                                          
tight junction protein 1ENSG00000104067TJP1chr15:29699367-29968865:-              0.12        0.14                                                                                                                0.12        0.1                                                        0.12                                                                  
tectonic family member 3ENSG00000119977TCTN3chr10:95663396-95694143:-                                      0.12                                                                                                                0.18        0.3                                                                                                          
GRAM domain containing 1BENSG00000023171GRAMD1Bchr11:123454398-123627774:+                                                                                                                                                              0.17                                        0.24                                                        0.17          
CD151 molecule (Raph blood group)ENSG00000177697CD151chr11:832843-839831:+                                                              0.13                                                        0.11                        0.17                                                                                                                0.15          
patatin like phospholipase domain containing 2ENSG00000177666PNPLA2chr11:818902-825573:+                                                              0.13                                                        0.11                        0.17                                                                                                                0.15          
hyaluronidase 2ENSG00000068001HYAL2chr3:50317790-50322906:-                      0.17                0.2                                                                                                                        0.19                                                                                                          
presenilin 1ENSG00000080815PSEN1chr14:73136418-73223691:+                      0.1                0.33                                                                                0.11                                                                                                                                                  
EPH receptor A2ENSG00000142627EPHA2chr1:16124337-16156087:-                      0.21                                                                                                                        0.11                                                0.21                                                                          
semaphorin 3BENSG00000012171SEMA3Bchr3:50267558-50277546:+                      0.17                                                                        0.18                                                                0.18                                                                                                          
myelin protein zero like 2ENSG00000149573MPZL2chr11:118253403-118264536:-                      0.23        0.3                                                                                                                                                                                                                                          
neural proliferation, differentiation and control 1ENSG00000107281NPDC1chr9:137039470-137046203:-                                                                                                                                                              0.22                                        0.17                                                        0.14          
piezo type mechanosensitive ion channel component 1ENSG00000103335PIEZO1chr16:88715343-88785211:-                                                                                                                                      0.12                0.19                                                        0.1                0.12                                          
ATP binding cassette subfamily B member 6 (Langereis blood group)ENSG00000115657ABCB6chr2:219209768-219218990:-                              0.34                                                0.18                                                                                                                                                                                          
solute carrier family 19 member 3ENSG00000135917SLC19A3chr2:227685210-227718012:-              0.33                                                                                                                                0.19                                                                                                                          
protein tyrosine kinase 2 betaENSG00000120899PTK2Bchr8:27311482-27459391:+              0.11                                                                                                                0.11                                                                0.18                                                        0.11                  
fukutin related proteinENSG00000181027FKRPchr19:46746046-46776988:+                                                                                                                                                              0.33                                                                                                0.19          
interleukin 17 receptor BENSG00000056736IL17RBchr3:53846580-53865800:+                      0.16                                                                                                                                        0.2                                        0.14                                                                  

 Showing page 32  		first page | previous page | next page | last page 








Contact us | | Terms & Conditions.
Copyright © 2020 University of Pennsylvania. All Rights Reserved.