Mutation

 

The putative cancer-causing HAMPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the HAMPs in each cancer type


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 HGNC Symbol  Ensembl Gene ID  ACC  BLCA  BRCA  CESC  CHOL  COAD  DLBC  ESCA  GBM  HNSC  KICH  KIRC  KIRP  LAML  LGG  LIHC  LUAD  LUSC  MESO  OV  PAAD  PCPG  PRAD  READ  SARC  SKCM  STAD  TGCT  THCA  THYM  UCEC  UCS  UVM 
HDAC10  ENSG00000100429                                                                                                                                      
HDAC6  ENSG00000094631                                                                                                                                      
HDAC7  ENSG00000061273                                                                                                                                      
HDAC4  ENSG00000068024                                                                                                                                      
HDAC5  ENSG00000108840                                                                                                                                      
HDAC9  ENSG00000048052                                                                                                        1                              
SIRT6  ENSG00000077463                                                                                                                                      
SIRT3  ENSG00000142082                                                                                                                                      
SIRT1  ENSG00000096717                                                                                                                            1          
SIRT2  ENSG00000068903                                                                                                                                      
SIRT7  ENSG00000187531                                                                                                                                      
SIRT4  ENSG00000089163                                                                                                                                      
SIRT5  ENSG00000124523                                                                                                                                      

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