Mutation

 

The putative cancer-causing HAMPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the HAMPs in each cancer type


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 HGNC Symbol  Ensembl Gene ID  ACC  BLCA  BRCA  CESC  CHOL  COAD  DLBC  ESCA  GBM  HNSC  KICH  KIRC  KIRP  LAML  LGG  LIHC  LUAD  LUSC  MESO  OV  PAAD  PCPG  PRAD  READ  SARC  SKCM  STAD  TGCT  THCA  THYM  UCEC  UCS  UVM 
KAT6A  ENSG00000083168                                                                                                                                      
KAT6B  ENSG00000156650                                                                                                                                      
KAT7  ENSG00000136504        1                1                                                                                                    1          
KAT5  ENSG00000172977                                                                                                                                      
KAT8  ENSG00000103510                                                                                                            1                          
CLOCK  ENSG00000134852                                                                                                                                      
HAT1  ENSG00000128708                                                                                                                                      
ELP3  ENSG00000134014                                                                                                                            1          
KAT2A  ENSG00000108773                                                                                                                                      
KAT2B  ENSG00000114166                                                                                                                            1          
TAF1  ENSG00000147133                1                                                                                                            1          
TAF1L  ENSG00000122728                                                                                                                                      
ATAT1  ENSG00000137343                                                                                                                                      
CREBBP  ENSG00000005339        1    1                                                            1                                                    1          
EP300  ENSG00000100393        1    1    1                    1    1                                1                                                    1          
GTF3C4  ENSG00000125484                                                                                                                                      
NCOA1  ENSG00000084676                                                                                                                                      
NCOA3  ENSG00000124151                                                                                                                                      
SP140  ENSG00000079263                                                                                                                                      
SP140L  ENSG00000185404                                        1                                                                                              

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