Mutation

 

The putative cancer-causing HAMPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the HAMPs in each cancer type


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 HGNC Symbol  Ensembl Gene ID  ACC  BLCA  BRCA  CESC  CHOL  COAD  DLBC  ESCA  GBM  HNSC  KICH  KIRC  KIRP  LAML  LGG  LIHC  LUAD  LUSC  MESO  OV  PAAD  PCPG  PRAD  READ  SARC  SKCM  STAD  TGCT  THCA  THYM  UCEC  UCS  UVM 
CECR2  ENSG00000099954                                                                                                                                      
KIAA2026  ENSG00000183354                                                                                                                                      
BRD1  ENSG00000100425                                                                                                                            1          
BRPF3  ENSG00000096070                                        1                                                                                              
BRPF1  ENSG00000156983        1                                                                                                                              
BRD7  ENSG00000166164                                                                1                                                                      
BRD9  ENSG00000028310                                                                                                                            1          
BAZ2A  ENSG00000076108            1                                                                                            1                              
BAZ2B  ENSG00000123636                                                                                                        1                    1          
ATAD2  ENSG00000156802                                        1                            1                                                        1          
ATAD2B  ENSG00000119778            1                            1                                                                                    1          
BRD8  ENSG00000112983                                                                                                                                      
BRWD3  ENSG00000165288                                                                                                                                      
BRWD1  ENSG00000185658                1                                                                            1            1                              
PHIP  ENSG00000146247                                                                                                        1                              
HDAC1  ENSG00000116478                                                                                                                                      
HDAC2  ENSG00000196591                        1                                                                                                    1          
HDAC3  ENSG00000171720                                                                                                                                      
HDAC8  ENSG00000147099                                                                                                                                      
HDAC11  ENSG00000163517                                                                                                                                      

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