This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
Overall distribution
Tissue specific distribution
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.64 (Driver)
Gscore (Del):
0.41
Recurrently amplified in 2 cancer type(s)
Recurrently deleted in 3 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
2.77 (Driver)
Recurrently mutated in 9 cancer type(s)
Overall
Tissue specific
Total fusion occurrence:
23 (Driver)
Fusions detected in 12 cancer type(s)
Overall
Tissue specific
RNAi: STRONGLY SELECTIVE
Functional class:
Epigenetic
JensenLab PubMed score:
76.54 (Percentile rank: 68.63%)
PubTator score:
52.55 (Percentile rank: 68.74%)
Target development/druggability level:
TbioThese targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: 1) target is above the cutoff criteria for Tdark; 2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code.
