The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Overall distribution
Tissue specific distribution
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.60
Gscore (Del):
0.00
Recurrently amplified in 1 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
0.80 (Driver)
Recurrently mutated in 5 cancer type(s)
Overall
Tissue specific
Total fusion occurrence:
8
Fusions detected in 5 cancer type(s)
Overall
Tissue specific
CRISPR: COMMON ESSENTIAL RNAi: COMMON ESSENTIAL
Functional class:
Epigenetic
JensenLab PubMed score:
159.68 (Percentile rank: 79.00%)
PubTator score:
60.59 (Percentile rank: 70.77%)
Target development/druggability level:
TbioThese targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: 1) target is above the cutoff criteria for Tdark; 2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code.
